Common therapies reduce depression in diabetics, study finds

(Medical Xpress)—People living with diabetes may be able to reduce the risk of developing depression and other mood disorders by including a common medication in the management of their condition.

The major 12-year study based on a Taiwanese cohort has shown the onset of diabetes increases the risk of , mainly depression, by more than two and a half times.

However the study, by researchers from Monash University and the National Health Research Institutes, Taiwan also found when metformin is included in the treatment of diabetes, the incidence of mood disorders was reduced by more than 50 per cent.

Metformin is the most commonly used medication for type 2 diabetes. Taken orally, it helps control .

Lead author, Emeritus Professor Mark Wahlqvist from Monash University's Department of Epidemiology and Preventive Medicine and the Monash Asia Institute, said the increasing prevalence of diabetes is revealing complications beyond the well-known ones affecting the cardiovascular system, the eyes, and feet.

"In earlier research we found that dementia and Parkinson's disease, the most common forms of known neurodegenerative disease, are more likely after the onset of diabetes," Professor Wahlqvist said.

"The same appears to be so for mood disorders including all forms of depression. We found depression and diabetes are more likely to occur together than would be expected from their respective separate prevalences."

The researchers found the risk of all mood disorders, dementia and Parkinson's disease were reduced by metformin, especially when used with a sulfonylurea drug, commonly used to stimulate the to produce more insulin, as treatment.

"It is possible that neurodegenerative processes are at work in diabetes-associated depression and that the use of metformin may minimise this risk," Professor Wahlqvist said.

"As the global burden of diabetes to health care systems increases, these findings may be relevant to the reduction of mental health complications associated with ."

The findings of this research was published in BioMed Central's open access journal BMC Medicine today.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.