Harnessing the ID in glioma

Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural stem cells. GICs drive tumor progression and must stay in a particular extracellular niche in order to maintain their cancer-promoting, stem cell-like characteristics.

In this issue of the , researchers led by Antonio Iavarone at Columbia University report on the role of ID proteins in glioma. ID proteins allow stem cells to stay anchored in a particular extracellular niche.

Using a mouse model of glioma, Iavarone and colleagues found that ID proteins were also responsible for retaining GICs in the extracellular niche that allowed them to maintain their cancer promoting properties. In human glioma patients, the expression of a group of Id-regulated genes was correlated with clinical outcomes.

These results suggest that ID proteins are important regulators of glioma and may be suitable therapeutic targets.

More information: Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis, Journal of Clinical Investigation, 2012.

Related Stories

'Housekeeping' mechanism for brain stem cells discovered

date Apr 22, 2012

Researchers at Columbia University Medical Center (CUMC) have identified a molecular pathway that controls the retention and release of the brain's stem cells. The discovery offers new insights into normal and abnormal neurologic ...

To combat deadly brain cancer, target the stem cells

date Jul 07, 2011

Researchers have uncovered a new target that could stop the growth of glioblastoma, a deadly form of brain cancer. In the July 8th issue of the journal Cell, a Cell Press publication, a new study identifies an enzyme found ...

Recommended for you

Protein's impact on colorectal cancer is dappled

date 6 hours ago

Researchers at University of California, San Diego School of Medicine have discovered a cell signaling pathway that appears to exert some control over initiation and progression of colorectal cancer, the ...

Colon cancer: Taking a step back to move forward

date 15 hours ago

Recent Weizmann Institute studies are revealing a complex picture of cancer progression in which certain genes that drive tumor growth in the earlier stages get suppressed in later stages - taking a step ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.