Harnessing the ID in glioma

December 17, 2012

Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural stem cells. GICs drive tumor progression and must stay in a particular extracellular niche in order to maintain their cancer-promoting, stem cell-like characteristics.

In this issue of the , researchers led by Antonio Iavarone at Columbia University report on the role of ID proteins in glioma. ID proteins allow stem cells to stay anchored in a particular extracellular niche.

Using a mouse model of glioma, Iavarone and colleagues found that ID proteins were also responsible for retaining GICs in the extracellular niche that allowed them to maintain their cancer promoting properties. In human glioma patients, the expression of a group of Id-regulated genes was correlated with clinical outcomes.

These results suggest that ID proteins are important regulators of glioma and may be suitable therapeutic targets.

Explore further: Brain tumor treatment may increase number of cancer stem-like cells

More information: Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis, Journal of Clinical Investigation, 2012.

Related Stories

To combat deadly brain cancer, target the stem cells

July 7, 2011

Researchers have uncovered a new target that could stop the growth of glioblastoma, a deadly form of brain cancer. In the July 8th issue of the journal Cell, a Cell Press publication, a new study identifies an enzyme found ...

'Housekeeping' mechanism for brain stem cells discovered

April 22, 2012

Researchers at Columbia University Medical Center (CUMC) have identified a molecular pathway that controls the retention and release of the brain's stem cells. The discovery offers new insights into normal and abnormal neurologic ...

Recommended for you

Molecularly shutting down cancer cachexia

August 30, 2016

Healthy fat tissue is essential for extended survival in the event of tumor-induced wasting syndrome (cachexia). In Nature Medicine, researchers at Helmholtz Zentrum München show that selective manipulation of an enzyme ...

Radiologists detect breast cancer in 'blink of an eye'

August 29, 2016

A new study by investigators at Brigham and Women's Hospital in collaboration with researchers at the University of York and Leeds in the UK and MD Andersen Cancer Center in Texas puts to the test anecdotes about experienced ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.