40 percent of cancer patients receive opioids at end of life

~40 percent of cancer patients receive opioids at end of life
For patients with one of five common cancers, 43.6 percent receive at least one prescription of opioids in the last three months of life, according to a study published in the Dec. 10 issue of the Journal of Clinical Oncology.

(HealthDay)—For patients with one of five common cancers, 43.6 percent receive at least one prescription of opioids in the last three months of life, according to a study published in the Dec. 10 issue of the Journal of Clinical Oncology.

Irene J. Higginson, B.M.B.S., Ph.D., and Wei Gao, Ph.D., from King's College London, used data from the United Kingdom General Practice Research Database to examine opioid prescribing rates in the last three months of life in a cohort of 29,825 patients diagnosed with lung, colorectal, female breast, prostate, and head and neck cancers. All patients died between 2000 and 2008.

The researchers found that 43.6 percent of patients received at least one prescription of opioids during the last three months of life, including the most prescribed opioids: 33.4 percent morphine, 11.6 percent diamorphine, and 10.2 percent fentanyl family. For opioids predominant during specific time periods, especially oxycodone, prescription rates increased over time. Compared with patients younger than 50 years, patients older than 60 years had significantly lower chances of receiving opioids, even after adjustment for comorbidity (prevalence ratio range, 0.14 to 0.78). Compared with men, women were slightly but significantly more likely to receive any opioid (prevalence ratio, 1.07). Compared with , morphine and diamorphine were more commonly prescribed for lung and , while fentanyl family drugs were more commonly prescribed for head and neck cancers.

"We found an encouraging increasing trend of opioid prescribing by general practitioners in the United Kingdom for patients with cancer who are in the last three months of life," the authors write. "However, people older than age 60 years were significantly underprescribed and should be targeted for improvement in their end-of-life ."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Opioids linked to higher risk of pneumonia in older adults

Sep 22, 2011

Opioids -- a class of medicines commonly given for pain -- were associated with a higher risk of pneumonia in a study of 3,061 adults, aged 65 to 94, e-published in advance of publication in the Journal of the American Ge ...

Recommended for you

WHO: Millions of Ebola vaccine doses ready in 2015

14 hours ago

The World Health Organization says millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines will start being tested in March.

Added benefit of vedolizumab is not proven

Oct 23, 2014

Vedolizumab (trade name Entyvio) has been approved since May 2014 for patients with moderately to severely active Crohn disease or ulcerative colitis. In an early benefit assessment pursuant to the Act on the Reform of the ...

Seaweed menace may yield new medicines

Oct 22, 2014

An invasive seaweed clogging up British coasts could be a blessing in disguise. University of Greenwich scientists have won a cash award to turn it into valuable compounds which can lead to new, life-saving drugs.

User comments