Etanercept seems beneficial in partial spinal cord injury

Etanercept seems beneficial in partial spinal cord injury
Treatment of rabbits with a partial spinal cord injury with the intramuscularly-administered tumor necrosis factor-α inhibitor etanercept is associated with improved clinical and electrophysiological recovery processes, according to research published in the December issue of the European Spine Journal.

(HealthDay)—Treatment of rabbits with a partial spinal cord injury (SCI) with the intramuscularly-administered tumor necrosis factor-α (TNF-α) inhibitor etanercept is associated with improved clinical and electrophysiological recovery processes, according to research published in the December issue of the European Spine Journal.

Fatih Bayrakli, M.D., of the Cumhuriyet University School of Medicine in Sivas, Turkey, and colleagues conducted an animal study involving 24 rabbits with partial SCI who were treated with either intramuscular saline or 2.5 mg/kg administered two to four hours after SCI or 12 to 24 hours after SCI.

The researchers found that Tarlov scores were significantly better in the two groups administered intramuscular etanercept, compared with the group that received saline. Two weeks after SCI, somatosensory-evoked potential recovery was significantly improved in both groups that received etanercept.

"Our results show that blocking the inflammation process in SCI by anti-TNF-α agent enhances clinical and electrophysiological recovery," the authors write. "These results are preliminary and will be a foundation for further studies using our SCI model and provide evidence of decreased inflammation, which is not sufficiently found in literature. These results also must be confirmed with different models, different drug doses, compression pressures, and drug timing schedules with further investigations."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Second bird flu case confirmed in Canada

14 hours ago

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

What exactly is coronavirus?

20 hours ago

The conflicts in Syria and Iraq are straining public health systems and public health efforts meant to prevent and detect the spread of infectious diseases. This is generating a "perfect storm" of conditions for outbreaks. Among the infections raising concern is Middle East Respiratory Syndrome, caused by a type of coronavirus, which emerged in 2012. ...

Scientists find Ebola virus is mutating

21 hours ago

(Medical Xpress)—Researchers working at Institut Pasteur in France have found that the Ebola virus is mutating "a lot" causing concern in the African countries where the virus has killed over eight thous ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.