Etanercept seems beneficial in partial spinal cord injury

Etanercept seems beneficial in partial spinal cord injury
Treatment of rabbits with a partial spinal cord injury with the intramuscularly-administered tumor necrosis factor-α inhibitor etanercept is associated with improved clinical and electrophysiological recovery processes, according to research published in the December issue of the European Spine Journal.

(HealthDay)—Treatment of rabbits with a partial spinal cord injury (SCI) with the intramuscularly-administered tumor necrosis factor-α (TNF-α) inhibitor etanercept is associated with improved clinical and electrophysiological recovery processes, according to research published in the December issue of the European Spine Journal.

Fatih Bayrakli, M.D., of the Cumhuriyet University School of Medicine in Sivas, Turkey, and colleagues conducted an animal study involving 24 rabbits with partial SCI who were treated with either intramuscular saline or 2.5 mg/kg administered two to four hours after SCI or 12 to 24 hours after SCI.

The researchers found that Tarlov scores were significantly better in the two groups administered intramuscular etanercept, compared with the group that received saline. Two weeks after SCI, somatosensory-evoked potential recovery was significantly improved in both groups that received etanercept.

"Our results show that blocking the inflammation process in SCI by anti-TNF-α agent enhances clinical and electrophysiological recovery," the authors write. "These results are preliminary and will be a foundation for further studies using our SCI model and provide evidence of decreased inflammation, which is not sufficiently found in literature. These results also must be confirmed with different models, different drug doses, compression pressures, and drug timing schedules with further investigations."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Recorded Ebola deaths top 7,000

17 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

22 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.