Fatty liver may directly mediate CAD in metabolic syndrome

Fatty liver may directly mediate CAD in metabolic syndrome
Men and women with fatty liver are more likely to have metabolic syndrome with type 2 diabetes, and women with fatty liver are more likely to have metabolic syndrome with subclinical atherosclerosis, according to research published online Dec. 18 in Diabetes Care.

(HealthDay)—Men and women with fatty liver are more likely to have metabolic syndrome (MetS) with type 2 diabetes, and women with fatty liver are more likely to have MetS with subclinical atherosclerosis, according to research published online Dec. 18 in Diabetes Care.

Juan G. Juárez-Rojas, Ph.D., of the National Institute of Cardiology in Mexico City, and colleagues conducted a study involving 765 people (52 percent women) without clinical atherosclerosis to study the role that fatty liver plays in the association of MetS with type 2 diabetes and (CAC). Fatty liver and CAC were determined using computed tomography.

The researchers found that fatty liver increased the association of MetS with type 2 diabetes in both women and men. Women and men with fatty liver were, respectively, 10.6- and 12.1-fold more likely to have MetS with . Additionally, women with fatty liver were 2.34-fold more likely to have MetS with CAC.

"Our study shows that isolated MetS is not independently associated with the presence of CAD. Consistent with findings of other studies, the prevalence of positive CAC was higher in men than in women," the authors write. "However, we found that fatty liver significantly favored the association of MetS with CAC only in women. Therefore, these results support the hypothesis that fatty liver may be not only a marker but even a direct mediator of atherosclerosis in women with MetS."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Fatty liver may herald impending type 2 diabetes

Feb 24, 2011

A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that individuals with fatty liver were five times more likely to develop type 2 diabetes than t ...

Fatty liver disease can lead to heart attack

Apr 19, 2011

Because of the prevalence of obesity in our country, many Americans are expected to develop a serious condition called non-alcoholic fatty liver disease (NAFLD), which can lead to cirrhosis, fibrosis, and in some cases liver ...

Recommended for you

Team shows why wound healing is impaired in diabetics

9 hours ago

One of the most troubling complications of diabetes is its effect on wound healing. Roughly 15 percent of diabetics will suffer from a non-healing wound in their lifetime. In some cases, these open ulcers on the skin lead ...

Progress in diabetes drug delivery

Jan 22, 2015

A drug therapy for diabetes treatment is being developed by an international research team led by WA scientists, which combines an existing anti-diabetic drug with bile acids to improve the drug's delivery ...

Roux-en-Y surgery can reverse insulin treatment in T2DM

Jan 21, 2015

(HealthDay)—Roux-en-Y gastric bypass surgery (RYGB) strongly predicts insulin cessation after surgery in insulin-treated type 2 diabetes (I-T2D) patients, independent of weight loss, according to a study ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.