Poor arthritis outcome risk up in overweight black women

Carmelita J. Colbert, M.D., from Northwestern University in Chicago, and colleagues analyzed whether excess body weight was associated with poorer four-year functional outcomes (as determined by the Western Ontario and McMaster Universities Osteoarthritis Index function, 20-meter walk and chair stand performance) in African-Americans compared with whites in 3,695 patients (16.1 percent African-American) with or at higher risk for knee osteoarthritis.

The researchers found that a higher body mass index and large waist circumference correlated with poorer outcomes. Among women with either feature, African-American women had a higher risk of poor outcomes, after adjusting for age, education, and income. The findings were potentially explained by income, comorbidity, depressive symptoms, pain, and disease severity. For men, findings were less consistent and were potentially explained by age and knee pain.

"Among Osteoarthritis Initiative women with excess body weight, African-Americans are at greater risk than whites for poor four-year outcome," Colbert and colleagues conclude. "Modifiable factors that may help to explain these findings in the Osteoarthritis Initiative include comorbidity, depressive symptoms, and knee pain."

The study was partially funded by Merck, Novartis, GlaxoSmithKline, and Pfizer as part of the Osteoarthritis Initiative, a public-private partnership.

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Journal reference: Arthritis Care & Research

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