Not all stem cells are equally efficient for use in regenerative medicine

January 9, 2013 in Medical research

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering. In a paper recently published in the prestigious journal Tissue Engineering the researchers report that, contrary to what was thought, only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes.

At present, CB-SCs are key to regenerative medicine and tissue engineering. From all types of CB-SC those called "Wharton's jelly stem cells (HWJSC)" are stirring up the interest of specialists in regenerative medicine, due to their accessibility and great ability to develop into several types of tissue and modulate immune responses.

Through a combination of microscopy and microanalysis essays, and the study of the genes involved in , the researchers discovered that only a specific group of (CB-SC) maintained in culture is useful for therapeutic purposes

The Most Suitable Cells

The relevance of this paper, which was the cover article in the journal Tissue Engineering, lies in the possibility to select the most suitable HWJSC for and regenerative medicine. According to these researchers, the different studies with HWJSC have obtained contradictory results because researchers failed to previously select the most suitable cell group.

The results of this study also open the possibility to select stem cell subgroups from different tissues, in order to improve the therapeutical efficacy of different regenerative medicine protocols.

More information: Tissue Eng Part C Methods . 2012 Jun;18(6):408-19. Evaluation of the Cell Viability of Human Wharton's Jelly Stem Cells for Use in Cell Therapy.

Provided by University of Granada search and more info website

send feedback to editors
not rated yet  

Rank not rated yet
Tags

cord blood stem cells, cell viability, tissue engineering, immune response, genes, tissue, regenerative medicine, stem cells
Related Stories
more news
Relevant PhysicsForums posts

More news stories

New study finds blind people have the potential to use their 'inner bat' to locate objects

New research from the University of Southampton has shown that blind and visually impaired people have the potential to use echolocation, similar to that used by bats and dolphins, to determine the location of an object.

Medical research created 15 minutes ago | popularity not rated yet | comments 0 | with audio podcast

Germ-fighting vaccine system makes great strides in delivery

A novel vaccine study from South Dakota State University (SDSU) will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference ...

Medical research created 37 minutes ago | popularity not rated yet | comments 0

Discovery of novel medicine for treatment of chronic wounds

Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal. To date, medical solutions that can change this situation are very limited. In his doctoral thesis Yue Shen from the Industrial ...

Medical research created 5 hours ago | popularity not rated yet | comments 0

Lymphatic fluid takes detour

When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the tissue. Such ...

Medical research created 5 hours ago | popularity not rated yet | comments 0 | with audio podcast

Computational tool translates complex data into simplified 2-dimensional images

In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...

Medical research created 23 hours ago | popularity 5 / 5 (3) | comments 0 | with audio podcast


First long-term study reveals link between childhood ADHD and obesity

A new study conducted by researchers at the Child Study Center at NYU Langone Medical Center found men diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) were twice as likely to be obese in a 33-year ...

Breakup of physician, drug company relationship could improve health care, cut cost

A new report suggests that improved health care and significant reductions in drug costs might be attained by breaking up the age-old relationship between physicians and drug company representatives who promote the newest, ...

Diabetes drug tested in Parkinson's disease patients

Parkinson's disease (PD) is a degenerative neurological disorder marked by a progressive loss of motor control. Despite intensive research, there are currently no approved therapies that have been demonstrated to alter the ...

Which women should be screened for high cholesterol?

National guidelines recommend that at-risk women be screened for elevated cholesterol levels to reduce their chances of developing cardiovascular disease. But who is 'at risk?' The results of a study by investigators ...

Women with severe injuries are less likely than men to be treated in a trauma center

Women are less likely than men to receive care in a trauma center after severe injury, according to a new study of almost 100,000 Canadian patients.

Neurons that can multitask greatly enhance the brain's computational power, study finds

Over the past few decades, neuroscientists have made much progress in mapping the brain by deciphering the functions of individual neurons that perform very specific tasks, such as recognizing the location ...