Not all stem cells are equally efficient for use in regenerative medicine

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering. In a paper recently published in the prestigious journal Tissue Engineering the researchers report that, contrary to what was thought, only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes.

At present, CB-SCs are key to regenerative medicine and tissue engineering. From all types of CB-SC those called "Wharton's jelly stem cells (HWJSC)" are stirring up the interest of specialists in regenerative medicine, due to their accessibility and great ability to develop into several types of tissue and modulate immune responses.

Through a combination of microscopy and microanalysis essays, and the study of the genes involved in , the researchers discovered that only a specific group of (CB-SC) maintained in culture is useful for therapeutic purposes

The Most Suitable Cells

The relevance of this paper, which was the cover article in the journal Tissue Engineering, lies in the possibility to select the most suitable HWJSC for and regenerative medicine. According to these researchers, the different studies with HWJSC have obtained contradictory results because researchers failed to previously select the most suitable cell group.

The results of this study also open the possibility to select stem cell subgroups from different tissues, in order to improve the therapeutical efficacy of different regenerative medicine protocols.

More information: Tissue Eng Part C Methods . 2012 Jun;18(6):408-19. Evaluation of the Cell Viability of Human Wharton's Jelly Stem Cells for Use in Cell Therapy.

add to favorites email to friend print save as pdf

Related Stories

New way to weed out problem stem cells, making therapy safer

Sep 27, 2012

Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult ...

Recommended for you

LED exposure is not harmful to human dermal fibroblasts

1 hour ago

There was a time when no one thought about light bulbs—one blew, you screwed another one in. Nowadays, it's more complicated, as energy efficiency concerns have given rise to a slew of options, including ...

Virtual bacteria shed light on cystic fibrosis infections

2 hours ago

The two species of bacteria are genetically similar – both contagious, both drug-resistant, both preying upon people with cystic fibrosis or weakened immune systems – yet they go about their sinister work very differently. ...

How the body fights against viruses

21 hours ago

Scientists of the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna, together with colleagues of the ETH Zurich, have now shown how double stranded RNA, such as viral ...

User comments