Not all stem cells are equally efficient for use in regenerative medicine

January 9, 2013

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering. In a paper recently published in the prestigious journal Tissue Engineering the researchers report that, contrary to what was thought, only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes.

At present, CB-SCs are key to regenerative medicine and tissue engineering. From all types of CB-SC those called "Wharton's jelly stem cells (HWJSC)" are stirring up the interest of specialists in regenerative medicine, due to their accessibility and great ability to develop into several types of tissue and modulate immune responses.

Through a combination of microscopy and microanalysis essays, and the study of the genes involved in , the researchers discovered that only a specific group of (CB-SC) maintained in culture is useful for therapeutic purposes

The Most Suitable Cells

The relevance of this paper, which was the cover article in the journal Tissue Engineering, lies in the possibility to select the most suitable HWJSC for and regenerative medicine. According to these researchers, the different studies with HWJSC have obtained contradictory results because researchers failed to previously select the most suitable cell group.

The results of this study also open the possibility to select stem cell subgroups from different tissues, in order to improve the therapeutical efficacy of different regenerative medicine protocols.

Explore further: Fat-derived stem cells hold potential for regenerative medicine

More information: Tissue Eng Part C Methods . 2012 Jun;18(6):408-19. Evaluation of the Cell Viability of Human Wharton's Jelly Stem Cells for Use in Cell Therapy.

Related Stories

New way to weed out problem stem cells, making therapy safer

September 27, 2012

Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult ...

Extracting stem cells from fat for tissue regeneration

May 3, 2011

Stem cells extracted from body fat may pave the way for the development of new regenerative therapies including soft tissue reconstruction following tumor removal or breast mastectomy surgery, the development of tissue-engineered ...

Recommended for you

Gut microbe movements regulate host circadian rhythms

December 1, 2016

Even gut microbes have a routine. Like clockwork, they start their day in one part of the intestinal lining, move a few micrometers to the left, maybe the right, and then return to their original position. New research in ...

Reactivation of embryonic genes leads to muscle aging

December 1, 2016

Developmental genes and pathways strictly regulate embryogenesis. The process is strongly driven by so-called Hox-genes. Now, researchers from the Leibniz Institute on Aging (FLI) in Jena, Germany, can show that one of these ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.