A new treatment for kidney disease-associated heart failure?

Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice.

In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tübingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced in klotho hypomorphic mice and increased their life span.

In a companion Attending Physician article, Darryl Quarles of the University of Tennessee discusses the implications of these findings for the treatment of CKD patients.

More information: Spironolactone-sensitive vascular calcification and Pit-1-dependent osteoblastic differentiation in klotho-hypomorphic mice, Journal of Clinical Investigation, 2013.
Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new, Journal of Clinical Investigation, 2013.

add to favorites email to friend print save as pdf

Related Stories

Anti-aging hormone Klotho may prevent complications

Feb 18, 2011

Low levels of the anti-aging hormone Klotho may serve as an early warning sign of the presence of kidney disease and its deadly cardiovascular complications, according to findings by UT Southwestern Medical Center researchers.

New blood test detects potentially deadly calcium deposits

Sep 06, 2012

A new test could help identify and treat individuals at risk of developing potentially deadly calcium deposits in their tissues and blood vessels, according to a study appearing in an upcoming issue of the Journal of the Am ...

Recommended for you

Depression tied to worse lumbar spine surgery outcomes

2 hours ago

(HealthDay)—Depressive symptoms are associated with poorer long-term outcome in patients undergoing surgery for lumbar spinal stenosis (LSS), according to research published in the Oct. 1 issue of The Sp ...

Ebola death toll edging to 4,900 mark: WHO

2 hours ago

The death toll in the world's worst-ever Ebola outbreak has edged closer to 4,900, while almost 10,000 people have now been infected, new figures from the World Health Organization showed Wednesday.

US to track everyone coming from Ebola nations

3 hours ago

U.S. authorities said Wednesday that everyone traveling into the U.S. from Ebola-stricken nations will be monitored for symptoms for 21 days. That includes returning American aid workers, federal health employees ...

US: Monitoring for all coming from Ebola nations

5 hours ago

U.S. health officials said Wednesday that they would begin monitoring all travelers—even Americans—who come to the U.S. from Ebola-stricken West African nations for 21 days, significantly expanding their vigilance.

User comments