Gene therapy may activate stem cells in heart failure patients

Gene therapy may activate stem cells in heart failure patients
Delivery of an SDF-1 encoding plasmid acts a homing signal for stem cells and improves clinical status in patients with symptomatic heart failure due to ischemic cardiomyopathy, according to a study published online Feb. 21 in Circulation Research.

(HealthDay)—Delivery of an SDF-1 encoding plasmid (JVS-100) acts a homing signal for stem cells and improves clinical status in patients with symptomatic heart failure due to ischemic cardiomyopathy (IsCM), according to a study published online Feb. 21 in Circulation Research.

Marc Penn, M.D., from Summa Health System in Akron, Ohio, and colleagues conducted a phase I, open-label, dose-escalation study (5, 15, or 30 mg of JVS-100 via endomyocardial injection) with 12 months follow-up in subjects with IsCM. The 17 subjects had New York Heart Association (NYHA) Class III , with an ≤40 percent on stable medical therapy.

The researchers found that at one month and four months the primary safety end point of no major adverse cardiac events was met. All cohorts demonstrated improvements in six-minute walk distance (6MWd), quality of life (QOL), and NYHA class at four months. Improvements over baseline in 6MWd were seen in the 15-mg and 30-mg dose groups (15 mg: Median [Range]: 41 [3 to 61] m; 30 mg: 31 [22 to 74] m), as were improvements in QOL (15 mg: −16 [+1 to −32] points; 30 mg: −24 [+17 to −38] points). Improvements in symptoms were maintained at 12 months.

"These data highlight the importance of defining the of stem cell-based tissue repair and suggest that over-expression of SDF-1 via gene therapy is a strategy for improving heart failure symptoms in patients with IsCM," the authors write.

One author is named as an inventor on for the use of SDF-1 to treat cardiovascular disease that have been licensed by Juventas Therapeutics, which funded the study.

More information: Abstract
Full Text
Editorial

add to favorites email to friend print save as pdf

Related Stories

SCAI: Ixmyelocel-T studied for dilated cardiomyopathy

May 15, 2012

(HealthDay) -- For patients with dilated cardiomyopathy, treatment with an autologous bone marrow-derived, expanded multi-cell product, ixmyelocel-T, is well tolerated and associated with improved symptoms ...

FDA: Zofran 32-mg dose pulled from market

Dec 06, 2012

(HealthDay)—The 32-mg, single intravenous dose of Zofran (ondansetron), an anti-nausea drug, is being removed from the market due to its potential to cause serious, even fatal, cardiac damage, according ...

FDA announces new limits on high-dose simvastatin (Zocor)

Jun 09, 2011

The United States Food and Drug Administration (FDA) today announced new limitations to the use of high-dose simvastatin, due to the increased risk of muscle pain and weakness (myopathy) and in rare cases, kidney damage and ...

Donepezil found helpful in dementia with lewy bodies

Jul 31, 2012

(HealthDay) -- For patients with dementia with Lewy bodies (DLB), treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to ...

Recommended for you

Vitamin D does not stop heart attack or stroke

22 hours ago

(Medical Xpress)—Taking vitamin D tablets cannot ward off heart attacks or stroke according to a new study from researchers at the University of East Anglia (UEA) published in the American Journal of Cl ...

New guidance on antithrombotic use in AF patients with ACS

22 hours ago

A new European joint consensus document on the use of antithrombotic drugs, including the non-vitamin K antagonist oral anticoagulants (NOACs), in patients with atrial fibrillation (AF) presenting with an acute coronary syndrome ...

User comments