French health estimates delve into Pill risk

A French drug watchdog on Tuesday released estimates for blood clots linked to birth control pills in the wake of fears that so-called third- and fourth-generation oral contraceptives boost a small risk of dangerous thrombosis.

Between 2000 and 2011, contraceptive pills were linked on average to 2,529 annual cases of blood clots, the National Agency for the Safety of Drugs and Health Products (ANSM) said.

Of the tally, 1,751 were attributable to third- and fourth generation pills, it said.

On average, 20 fatalities annually could be linked to contraceptive use, six of which could be attributed to first- and second-generation pills and 14 to the later-generation pills, the agency said.

"The risk of venous applies to the population as a whole, but the risk is low," the ANSM said in a press release.

"It increases with age for all women, regardless of whether they use or not. It is higher for users of third- and fourth-generation contraceptives than for users of first- and second-generation contraceptives," it said, reiterating an earlier judgement.

Clots that lodge in the veins can be highly dangerous, potentially causing strokes or heart attacks.

The ANSM estimates are based on a , not on an analysis of individual cases. Smoking and obesity are also associated with higher risk of clots.

More than four million women annually took oral contraceptives during the 2001-2011 period, roughly half of whom took first- and second-generation pills and the remainder third- and fourth-generation.

The third-generation Pill, introduced in the 1990s, and the fourth generation, approved in the last decade, are formulated to have synthetic versions of the progestogen, the idea being to skirt side-effects associated with older contraceptives.

In January, the called on doctors to prescribe third- and fourth-generation pills only "in very specific circumstances" and never as a first option.

It also urged the European Medicines Agency (EMA) to alter its guidelines accordingly. The EMA said on January 28 that it would study the request.

The health ministry also dropped the two later generations of the Pill from the list of medications that are reimbursed under France's national health-insurance programme.

The ANSM said that figures for February showed a slump in sales of 34 percent for third- and fourth-generation pills, and a rise of 27 percent for first- and second-generation alternatives, as women made the switch.

The storm in France has been triggered in part by the case of a 25-year-old woman, Marion Larat, who was left badly handicapped by a stroke that, in a lawsuit, she attributes to a later-generation pill made by Bayer.

A Danish study published in the British Medical Journal in 2011 found women who took one of the newer types of Pill ran twice the risk of developing venous thromboembolism compared to counterparts who used older-generation pills.

Compared with non-users of the Pill, the risk of a clot was between three and six times higher.

In absolute terms, though, the risk from the newer contraceptives was small, the investigators said.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

US approves new, hard-to-abuse hydrocodone pill (Update)

Nov 20, 2014

U.S. government health regulators on Thursday approved the first hard-to-abuse version of the painkiller hydrocodone, offering an alternative to a similar medication that has been widely criticized for lacking ...

Soaring generic drug prices draw Senate scrutiny

Nov 20, 2014

Some low-cost generic drugs that have helped restrain health care costs for decades are seeing unexpected price spikes of up to 8,000 percent, prompting a backlash from patients, pharmacists and now Washington ...

Only half of patients take their medications as prescribed

Nov 20, 2014

The cost of patients not taking their medications as prescribed can be substantial in terms of their health. Although a large amount of research evidence has tried to address this problem, there are no well-established ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.