Activated carotid bodies key in metabolic disruption

Activated carotid bodies key in metabolic disruption
Activation of carotid bodies by insulin may account for increased sympathoadrenal activity that results in insulin resistance and arterial hypertension, according to an experimental study published online March 25 in Diabetes.

(HealthDay)—Activation of carotid bodies (CB) by insulin may account for increased sympathoadrenal activity that results in insulin resistance (IR) and arterial hypertension, according to an experimental study published online March 25 in Diabetes.

Maria J. Ribeiro, from Universidade Nova de Lisboa in Portugal, and colleagues examined the role of CB in animal models of IR and hypertension and tested whether insulin is a trigger for CB activation.

The researchers found that CB overstimulation seems to be involved in the etiology of IR and hypertension, with increased CB activity seen in IR animal models. Resection of the carotid sinus nerve prevented CB overactivation and was found to prevent diet-induced IR and hypertension. In further experiments, insulin was found to trigger CB activation.

"In conclusion, we propose that insulin-triggered CB activation is responsible for increased sympathoadrenal activity and outflow creating a vicious cycle that culminates in severe IR and , the core features of the metabolic syndrome and type 2 diabetes," write the authors.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Liver insulin resistance correlates with cardiac risk

date Apr 16, 2012

(HealthDay) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, ...

Insulin resistance increases risk of colorectal adenomas

date Mar 27, 2012

(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according ...

Recommended for you

EBV co-infection may boost malaria mortality in childhood

date 14 hours ago

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according ...

Three important things you didn't know about diabetes

date 20 hours ago

When we think of diabetes, we tend to think of rich people with poor lifestyles. A chronic disease linked with obesity, heart disease and worse outcomes for some infectious diseases, diabetes tends to be ...

Changes observed in HbA1c during ramadan

date May 20, 2015

(HealthDay)—For patients with type 2 diabetes, during Ramadan, the greatest change among metabolic parameters is seen for glycemia, according to a study published online May 13 in the Journal of Diabetes In ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.