Central adiposity may affect renal hemodynamics

April 13, 2013
Central adiposity may affect renal hemodynamics
Regardless of body mass index, higher waist-to-hip ratio, a measure of central adiposity, is associated with lower glomerular filtration rate, lower effective renal plasma flow, and higher filtration fraction, according to research published online April 11 in Journal of the American Society of Nephrology.

(HealthDay)—Regardless of body mass index (BMI), higher waist-to-hip ratio (WHR), a measure of central adiposity, is associated with lower glomerular filtration rate (GFR), lower effective renal plasma flow (ERPF), and higher filtration fraction (FF), according to research published online April 11 in Journal of the American Society of Nephrology.

Arjan J. Kwakernaak, M.D., of University Medical Center Groningen in the Netherlands, and colleagues evaluated the association between anthropometric (WHR and BMI) and renal hemodynamic parameters in 315 healthy adults.

According to the researchers, WHR was negatively associated with GFR and ERPF, and positively associated with FF. These findings held even after adjustment for sex, age, mean arterial pressure, and BMI, with similar results in multivariate models regardless of whether the hemodynamic measures were indexed to body surface area.

"In conclusion, a higher WHR was associated with lower GFR and ERPF, and with higher FF, in healthy persons; these are considered an unfavorable renal hemodynamic profile," the authors write. "Of note, this association was independent of BMI. These data suggest the possibility that an altered renal hemodynamic profile is involved in the long-term renal risk associated with , as seen in epidemiologic studies."

Explore further: Poorer outcomes linked with certain hormone for patients with early-stage chronic kidney disease

More information: Abstract
Full Text

Related Stories

Recommended for you

Monkey study shows Zika infection prolonged in pregnancy

June 28, 2016

University of Wisconsin-Madison researchers studying monkeys have shown that one infection with Zika virus protects against future infection, though pregnancy may drastically prolong the time the virus stays in the body.

Teaching an old drug new tricks to fight cytomegalovirus

June 27, 2016

Researchers at Johns Hopkins have found that an old drug once mostly used to treat amebiasis—a disease caused by a parasite—and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.