Central adiposity may affect renal hemodynamics

Central adiposity may affect renal hemodynamics
Regardless of body mass index, higher waist-to-hip ratio, a measure of central adiposity, is associated with lower glomerular filtration rate, lower effective renal plasma flow, and higher filtration fraction, according to research published online April 11 in Journal of the American Society of Nephrology.

(HealthDay)—Regardless of body mass index (BMI), higher waist-to-hip ratio (WHR), a measure of central adiposity, is associated with lower glomerular filtration rate (GFR), lower effective renal plasma flow (ERPF), and higher filtration fraction (FF), according to research published online April 11 in Journal of the American Society of Nephrology.

Arjan J. Kwakernaak, M.D., of University Medical Center Groningen in the Netherlands, and colleagues evaluated the association between anthropometric (WHR and BMI) and renal hemodynamic parameters in 315 healthy adults.

According to the researchers, WHR was negatively associated with GFR and ERPF, and positively associated with FF. These findings held even after adjustment for sex, age, mean arterial pressure, and BMI, with similar results in multivariate models regardless of whether the hemodynamic measures were indexed to body surface area.

"In conclusion, a higher WHR was associated with lower GFR and ERPF, and with higher FF, in healthy persons; these are considered an unfavorable renal hemodynamic profile," the authors write. "Of note, this association was independent of BMI. These data suggest the possibility that an altered renal hemodynamic profile is involved in the long-term renal risk associated with , as seen in epidemiologic studies."

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Routines most vital in avoiding Ebola infection: WHO

2 hours ago

Meticulously following stringent routines when putting on and removing protective equipment is more important than the kind of gear health care workers use to ward off Ebola infection, the World Health Organization said Friday.

A look at latest Ebola developments

3 hours ago

No African countries are on the United Nations list of contributors to fight Ebola. With few exceptions, African governments and institutions are offering only marginal support as the continent faces its ...

Liberia opens one of largest Ebola treatment centers

4 hours ago

Remembering those who have died in the world's deadliest Ebola outbreak, Liberia's president opened one of the country's largest Ebola treatment centers in Monrovia on Friday amid hopes that the disease is ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.