Polymorphism in estrogen receptor alpha linked to back pain

April 11, 2013
Polymorphism in estrogen receptor α linked to back pain
For women with degenerative spondylolisthesis, polymorphisms in the estrogen receptor α (ERα) are associated with back pain intensity, according to a study published in the April issue of the Journal of Spinal Disorders and Techniques.

(HealthDay)—For women with degenerative spondylolisthesis (DS), polymorphisms in the estrogen receptor α (ERα) are associated with back pain intensity, according to a study published in the April issue of the Journal of Spinal Disorders and Techniques.

Hyoung Lok Roh, M.D., from Pusan National University School of Medicine in the Republic of Korea, and colleagues examined the correlation between polymorphisms in the ERα and pain intensity in female DS patients. Data were collected for 192 patients with DS for PvuII and XbaI polymorphisms, , pain intensity at the leg and lower back, and radiological and anthropometric findings.

The researchers found that the XbaI polymorphism was significantly correlated with the visual analog scale score of back pain, with the visual analog scale significantly higher in patients with GG genotype compared with the AG or AA genotypes. In haplotype analyses of the PvuII and XbaI polymorphisms, the presence of the CG haplotype correlated with the intensity of back pain.

"We found ERα gene polymorphism using XbaI to be associated with back in DS patients," the authors write. "However, further studies on a larger number of subjects will be needed."

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not rated yet Apr 11, 2013
Dear Editors,
Thank you for including the caveat
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Please put this on ALL physorg.com postings that require it. I spend a lot of time going to the sites only to be disappointed that, as a have-not, I cannot access the information. So much for that political tennent in academia for lowering the barrier between haves and havenots.

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