Integrated model can predict preeclampsia in first trimester

Integrated model can predict preeclampsia in first trimester
An integrated model for first-trimester screening of preeclampsia seems effective in a routine care setting, according to a study published in the March issue of the American Journal of Obstetrics & Gynecology.

(HealthDay)—An integrated model for first-trimester screening of preeclampsia (PE) seems effective in a routine care setting, according to a study published in the March issue of the American Journal of Obstetrics & Gynecology.

Elena Scazzocchio, M.D., from the University of Barcelona in Spain, and colleagues used data from a cohort of 5,170 singleton pregnancies who underwent routine first-trimester screening (2009 to 2011) to examine the effectiveness of an integrated screening test to predict PE. Using maternal characteristics; levels of pregnancy-associated plasma protein-A and free β-human chorionic gonadotropin at 8 to 12 weeks; and blood pressure and uterine artery Doppler at 11.0 to 13.6 weeks, a predictive of early- and late-onset PE was constructed.

The researchers found that 2.6 percent of participants developed PE (early PE, 0.5 percent; late PE, 2.1 percent). For early PE, the detection rates were 69.2 percent and 80.8 percent for false-positive rates of 5 and 10 percent, respectively (area under the curve, 0.95). For late PE, the corresponding detection rates were 29.4 and 39.6 percent, respectively (area under the curve, 0.71).

"First-trimester combining maternal factors with uterine artery Doppler, blood pressure, and pregnancy-associated plasma protein-A is useful to predict PE in a routine care setting," write the authors.
The study was funded by Siemens Healthcare Diagnostics.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Unsuspected PE seldom linked to death in cancer patients

Oct 09, 2012

(HealthDay)—Unsuspected pulmonary embolism (UPE) is not associated with an increased risk of death in cancer patients when compared to patients without pulmonary embolism (PE), according to research published ...

Recommended for you

Ob-gyn guidance issued for young cancer patient concerns

Jul 25, 2014

(HealthDay)—Young cancer patients and survivors may have gynecologic concerns, which should be managed before, during, and after treatment, according to a Committee Opinion published in the August issue ...

Common blood thinner for pregnant women proven ineffective

Jul 24, 2014

It's a daily injection to the belly for pregnant women at risk of developing blood clots and it's ineffective, according to a clinical trial led by researchers at The Ottawa Hospital and published today by the prestigious ...

Improving life before it begins

Jul 22, 2014

A group of Mexican specialists in fetal medicine have successfully performed over 200 surgeries on unborn babies, inside the womb of the mother. Doctors, grouped under the signature Fetal Medicine Mexico, ...

User comments