Sofosbuvir shows promise for chronic hepatitis C infection

Sofosbuvir shows promise for chronic hepatitis C infection
Sofosbuvir seems to be a promising treatment option for patients with chronic hepatitis C virus infection, according to two studies published online April 23 in the New England Journal of Medicine to coincide with presentation at The International Liver Congress, the annual meeting of the European Association for the Study of the Liver, held from April 24 to 28 in Amsterdam.

(HealthDay)—Sofosbuvir seems to be a promising treatment option for patients with chronic hepatitis C virus (HCV) infection, according to two studies published online April 23 in the New England Journal of Medicine to coincide with presentation at The International Liver Congress, the annual meeting of the European Association for the Study of the Liver, held from April 24 to 28 in Amsterdam.

Ira M. Jacobson, M.D., from Weill Cornell Medical College in New York, and colleagues conducted two randomized phase 3 studies involving patients with chronic HCV genotype 2 or 3. The researchers found that the rate of sustained was 78 percent with sofosbuvir and ribavirin versus 0 percent with placebo in patients for whom peginterferon treatment was not an option. For previously treated non-responders, the rate of response with sofosbuvir and ribavirin was 50 percent at 12 weeks and 73 percent at 16 weeks.

Eric Lawitz, M.D., from the Texas Liver Institute in San Antonio, and colleagues conducted two phase 3 studies in previously untreated patients with HCV. The researchers found that in a single-group study the sustained virologic response was 90 percent with a 12-week regimen of sofosbuvir plus peginterferon alfa-2a and ribavirin. In the non-inferiority trial, the sustained virologic response was 67 percent for patients treated with 12 weeks of sofosbuvir plus ribavirin and 67 percent for those treated with 24 weeks of -2a plus ribavirin.

"The data from the sofosbuvir trials suggest that a radical change in clinical practice is imminent," write the authors of an accompanying editorial.

Several authors from the Jacobson study disclosed financial ties to pharmaceutical companies, including Gilead Sciences, which manufactures sofosbuvir and funded both studies.

More information: Full Text - Jacobson
Full Text - Lawitz
Editorial
More Information

Related Stories

New treatment therapy helps inhibit hepatitis C

Jul 31, 2008

Two new studies examine the use of the nucleoside polymerase inhibitor, R1626, to the standard therapy for hepatitis C. The reports appear in the August issue of Hepatology, a journal published by John Wiley & Sons on beh ...

Coffee drinking improves hepatitis C treatment response

Jun 07, 2011

Advanced hepatitis C patients with chronic liver disease may benefit from drinking coffee during treatment, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) ...

Recommended for you

Ebola isolation at US base 'pretty much vacation'

1 hour ago

With plenty of flat screen TVs, game nights and even an outdoor fire pit, life in isolation for members of the U.S. military who have returned from the Ebola mission in West Africa can look a lot like summer camp.

Chinese-built Ebola center dedicated in Liberia

4 hours ago

China, one of the first countries to send aid to battle Ebola in West Africa, ramped up the assistance significantly Tuesday by opening a 100-bed treatment center in Liberia as rows of uniformed Chinese army ...

Superbug in SE Michigan shows recent decline

7 hours ago

A new study finds a decrease in an emergent strain of methicillin-resistant S. aureus (MRSA) that is resistant to last line defense antibiotics. Researchers examined the prevalence of vancomycin-resistant Staphylococcus aureus (V ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.