ECE: Gene variants linked to reduced male fertility

May 3, 2013
ECE: gene variants linked to reduced male fertility
Particular gene variants of follicle stimulating hormone and its receptor are associated with significantly reduced fertility in men, according to a study presented at the annual European Congress of Endocrinology, held from April 27 to May 1 in Copenhagen.

(HealthDay)—Particular gene variants of follicle stimulating hormone (FSH) and its receptor are associated with significantly reduced fertility in men, according to a study presented at the annual European Congress of Endocrinology, held from April 27 to May 1 in Copenhagen.

Joerg Gromoll, Ph.D., from the Centre of Reproductive Medicine in Muenster, Germany, and colleagues genotyped 1,213 male partners in and 365 women with normal reproductive function for a single nucleotide polymorphism (SNP) in the promoter of the FSH subunit B (−211G>T) and a SNP in the FSH receptor (2039A>G). Both SNPs had been associated with FSH levels.

The researchers found that men with the FSH subunit B variant had lower levels of serum FSH, reduced bi-testicular volume, and higher levels of luteinizing hormone (LH). The effect on serum FSH and testicular volume was even more pronounced in men who also had the FSH receptor variant and was associated with a 34 percent drop in sperm count. Women with the FSH subunit B variant had higher levels of serum FSH and LH but reduced progesterone. The FSH receptor variant was also associated with higher serum FSH in women.

"The SNPs in the FSH subunit B and FSH have significant impact on reproductive parameters in both sexes and the combinatory effects of variants in hormone and receptor are an unparalleled example in endocrinology," Gromoll and colleagues conclude.

Explore further: New weekly fertility injections work as well as daily

More information: Abstract
More Information

Related Stories

New weekly fertility injections work as well as daily

June 12, 2012

New long-lasting weekly injections of fertility hormones are as safe and effective as standard daily injections, according to Cochrane researchers. The researchers compared weekly and daily hormone injections in a Cochrane ...

The regulation of puberty and maturation in cod

February 18, 2013

FSH and LH are two important hormones which regulate the processes of puberty and maturation. These hormones are secreted by the pituitary gland and are transported in the blood to the genitalia, where they regulate maturation.

FSH, inhibin B poor predictors of sperm count after cancer

March 8, 2013

(HealthDay)—Serum levels of follicle-stimulating hormone (FSH) and inhibin B are not good predictors of sperm levels in male survivors of childhood cancer, according to a study published online Feb. 19 in the Journal of ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.