New technique alleviates painful bone metastases

A high-dose of ultrasound targeted to painful bone metastases appears to quickly bring patients relief, and with largely tolerable side effects, according to new research presented by Fox Chase Cancer Center scientists at the 49th Annual Meeting of the American Society of Clinical Oncology on Monday, June 3.

During the procedure, known as MR-guided focused ultrasound, doctors direct a concentrated beam of energy to specific nerve endings that are causing pain in . These patients typically have a significant amount of discomfort—half of rated their pain at least a 7 out of 10—but within a handful of days, most said they felt significant relief.

Although Fox Chase patients received during the procedure, the most commonly reported side effect was pain—which can often be alleviated with additional anesthesia, says study author Joshua Meyer, MD, attending physician in the Radiation Oncology Department at Fox Chase. "That's , which is gone as soon as the procedure is over," he says. "The whole reason we're doing the procedure is for the pain relief that comes afterwards. And that's relatively quick—we see a response by a day or so, and within three days of the procedure most patients are reporting a significant improvement."

Specifically, 67% of the 107 treated patients said their pain was "much improved" after the treatment, and that relief continued through the end of the three-month study. In comparison, among a group of 35 patients that received a "sham" treatment—they entered the machine but did not receive the intervention—only 20% reported some pain relief, Meyer and his colleagues reported.

During the procedure, patients enter into an , which allows clinicians to direct a cone of ultrasound energy at specific, targeted bone sites that are causing pain. The MRI also acts as a thermometer to measure the temperature deep within the body created by the high dose of energy, which generates enough heat to burn the nerve endings that are causing pain.

Although pain relief was durable until the end of the study at 90 days, it's not clear how much longer the pain relief lasts, says Meyer. "We've had reports of patients experiencing pain relief up to a year or more outside of the study."

Typically, patients with bone are treated with radiation, which shrinks the bone cancer that is putting pressure on , causing pain. This technique also treats the cancer (MR-guided focused ultrasound may not), but often takes weeks before patients experience , and not all will respond, says Meyer. In addition, others may not be eligible to receive additional radiation, if they have limited bone marrow function, for instance, he notes. The latest research didn't compare the effectiveness of the ultrasound technique to radiation, but the response to ultrasound appears "within the same ballpark of that in previous studies with radiation."

MR-guided focused ultrasound has been approved by the U.S. Food and Drug Administration, and is available at Fox Chase Cancer Center, as well as a handful of other facilities around the country.

Related Stories

Freezing nerves knocks pain out cold

date Apr 14, 2013

Using a tiny ball of ice, a minimally invasive interventional radiology treatment called cryoneurolysis safely short circuits chronic pain caused by nerve damage, according to data being presented at the Society of Interventional ...

Recommended for you

Study finds new potential melanoma drug target

date May 02, 2015

A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published online today in the journal Clinical Ca ...

Surgery for terminal cancer patients still common

date May 02, 2015

The number of surgeries performed on terminally ill cancer patients has not dropped in recent years, despite more attention to the importance of less invasive care for these patients to relieve symptoms and ...

Study provides comprehensive look at brain cancer treatments

date May 01, 2015

Led by the Translational Genomics Research Institute (TGen) and UC San Francisco (UCSF), a comprehensive genetic review of treatment strategies for glioblastoma brain tumors was published today in the Oxford University Press ...

How artificial tanning can lead to melanoma

date May 01, 2015

Young women may be up on the latest fashions and trends as they prepare for prom season. But what many don't know is that the tan that looks oh-so-good with their dress may be the first step toward skin cancer.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.