Researchers determine that brain reserve independently protects against cognitive decline in MS

June 25, 2013

U.S. and Italian researchers have determined that brain reserve, as well as cognitive reserve, independently protects against cognitive decline in multiple sclerosis (MS). Their article, "Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it", was published in Neurology on June 11, 2013 (Neurology 2013;80:2186-2193). Authors James Sumowski, PhD, Victoria Leavitt, PhD, and John DeLuca, PhD, are with Kessler Foundation in West Orange, NJ. Maria Rocca, MD, Gianna Riccitelli, PhD, Giancarlo Comi, MD, and Massimo Filippi, MD, are with San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

"Our research interests focus on why many people with MS suffer , while others with MS withstand considerable without ," said Dr. DeLuca, VP for Research & Training at Kessler Foundation. "With our colleagues in Milan, we explore factors associated with lack of cognitive decline despite marked changes on imaging studies." In this study, 62 patients with MS (41 relapsing-remitting MS, 21 secondary progressive MS) had MRIs to estimate brain reserve and disease burden. Early-life cognitive leisure was measured as a source of cognitive reserve. Cognitive status was measured with tasks of cognitive efficiency and memory.

Dr. Sumowski, principal author/investigator, commented on the importance of the study, saying, "We demonstrated for the first time that larger maximal lifetime brain growth (which is heritable) and early life mental stimulation (e.g., reading, games, hobbies) independently and differentially protect against cognitive decline in MS. That is, genetics and life experience independently protect against cognitive decline in persons with MS." Foundation scientists have previously documented the protective effect of intellectual enrichment in MS.

Explore further: People with MS-related memory and attention problems have signs of extensive brain damage

More information: Sumowski JF, Wylie GR, Chiaravalloti N, DeLuca J. Intellectual enrichment lessens the effect of brain atrophy on learning and memory in multiple sclerosis. Neurology. 2010 Jun 15;74(24):1942-5.

Sumowski JF, Wylie GR, Leavitt VM, Chiaravalloti ND, DeLuca J. Default network activity is a sensitive and specific biomarker of memory in multiple sclerosis. Mult Scler. 2013 Feb;19(2):199-208.

Related Stories

Recommended for you

Scientists identify neurons devoted to social memory

September 30, 2016

Mice have brain cells that are dedicated to storing memories of other mice, according to a new study from MIT neuroscientists. These cells, found in a region of the hippocampus known as the ventral CA1, store "social memories" ...

Throwing light on the brain's perception of transparency

September 30, 2016

Researchers have created a new optical illusion that helps reveal how our brains determine the material properties of objects – such as whether they are transparent, shiny, matte or translucent – just from looking at ...

Some brains are blind to moving objects

September 28, 2016

As many as half of people are blind to motion in some part of their field of vision, but the deficit doesn't have anything to do with the eyes.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.