Duloxetine moderately cost-effective for treating back pain

Duloxetine moderately cost-effective for treating back pain
Duloxetine is a moderately cost-effective treatment for chronic low back pain compared with other post-first-line oral medications, according to research published in the May 15 issue of Spine.

(HealthDay)—Duloxetine is a moderately cost-effective treatment for chronic low back pain (CLBP) compared with other post-first-line oral medications, according to research published in the May 15 issue of Spine.

Ronald Wielage, M.P.H., from Medical Decision Modeling in Indianapolis, and colleagues created a model based on the 2008 osteoarthritis clinical guidelines of the National Institute for Health and Clinical Excellence (NICE). Meta-analysis estimated treatment-specific utilities, and a transfer-to-utility regression was estimated from CLBP trial data. The NICE model and meta-analysis estimated adverse event rates of comparator treatments. Published literature and Quebec and Ontario public sources were used to derive costs.

The researchers found that naproxen, celecoxib, and duloxetine were the most cost-effective in the base case, with naproxen the least expensive medication. Celecoxib had an incremental cost-effectiveness ratio of $19,881, and duloxetine's was $43,437. Other comparators were dominated. Rates of cardiovascular and gastrointestinal adverse events and usage drove up costs. For a population 65 years or older, the incremental cost-effectiveness ratio for duloxetine fell to $21,567, while for a population at higher risk of cardiovascular and gastrointestinal adverse events, it fell to $18,726.

"The model estimates that duloxetine is a moderately cost-effective treatment for CLBP, becoming more cost-effective for populations older than 65 years or at greater risk of cardiovascular and gastrointestinal events," the authors write.

The study was funded in part by Eli Lilly, the manufacturer of duloxetine.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Low-dose duloxetine deemed safe for urinary incontinence

Jul 27, 2012

(HealthDay) -- Duloxetine appears safe for the routine clinical care of women with stress urinary incontinence (SUI), according to a study published online July 23 in the British Journal of Clinical Pharmacology.

Medication duloxetine helps reduce pain from chemotherapy

Apr 02, 2013

Among patients with painful chemotherapy-induced peripheral neuropathy, use of the anti-depressant drug duloxetine for 5 weeks resulted in a greater reduction in pain compared with placebo, according to a study in the April ...

Drugs similar in efficacy for neuropathic pain in diabetes

Sep 26, 2012

(HealthDay)—In the treatment of patients with chronic diabetic peripheral neuropathic pain (DPNP), there are no significant differences in pain-relief efficacy between amitriptyline, duloxetine, and pregabalin; however, ...

Recommended for you

US looking past Ebola to prepare for next outbreak

5 hours ago

The next Ebola or the next SARS. Maybe even the next HIV. Even before the Ebola epidemic in West Africa is brought under control, U.S. public health officials are girding for the next health disaster.

Can robots help stop the Ebola outbreak?

13 hours ago

The US military has enlisted a new germ-killing weapon in the fight against Ebola—a four-wheeled robot that can disinfect a room in minutes with pulses of ultraviolet light.

New bird flu case in Germany

14 hours ago

A worrying new strain of bird flu has been observed for the first time in a wild bird in northern Germany, the agriculture ministry said Saturday.

Mali announces new Ebola case

Nov 22, 2014

Mali announced Saturday a new case of Ebola in a man who is fighting for his life in an intensive care unit in the capital Bamako.

Plague outbreak kills 40 in Madagascar: WHO

Nov 22, 2014

An outbreak of plague has killed 40 people in Madagascar, the World Health Organization said, warning that the disease could spread rapidly in the country's densely populated capital Antananarivo.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.