Exposure to low doses of BPA linked to increased risk of prostate cancer in human stem cells

Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new study finds. The results were presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco.

BPA is a that is used to add flexibility to many common products, including food cans and containers, compact discs, eyeglasses, and even . It is universally prevalent, and tests indicate that almost everyone has measurable levels of the chemical in their bodies.

The chemical has received a great deal of media attention in recent years because of its potential to increase the risk of disease. The concern about BPA in the human body is that it is an endocrine-disrupting chemical, which means that it alters the body's by replicating the activity of a naturally occurring hormone. In this case, BPA replicates the activity of estrogen. Of greatest concern are BPA's effects on developing fetuses and infants because endocrine-disrupting chemicals are thought to predispose developing cells to later disease.

In this study, investigators used human prostate stem cells from to grow in a mouse model. They found that early BPA exposure significantly increased the risk of both prostate cancer and a known as prostate epithelial neoplasia, or PIN. The incidence rates for PIN and prostate cancer were:

  • 12 percent of non-BPA exposed tissue
  • 33-45 percent of tissue exposed to BPA

"These results suggest that stem cells are direct BPA targets which may explain the long-lasting effects of this chemical throughout the body," said study lead author Gail S. Prins, Ph.D., professor of physiology and urology at the University of Illinois at Chicago. "They provide the first direct in vivo evidence that developmental exposure to environmentally relevant levels of BPA increases human prostate cancer risk."

Investigators were able to observe the effects of BPA on living prostate tissue by isolating prostate from young men, then combining these cells with undifferentiated cells called mesenchyme, which, for this study, derived from rat tissue. They then grafted this combined tissue to the kidneys of mice where the tissue developed into human prostate tissue. To simulate human BPA exposure, the investigators fed at levels found in humans to the study mice for the first two weeks of the prostate-tissue formation.

One month after the tissue graft, when the prostate tissue had matured, the investigators administered estrogen and testosterone at elevated levels to the study mice to promote prostate disease.

The National Institutes of Health's National Institute of Environmental Health Sciences funded the study.

add to favorites email to friend print save as pdf

Related Stories

Prenatal exposure to BPA affects fat tissues in sheep

Jun 17, 2013

New research suggests that fetal exposure to the common environmental chemical bisphenol A, or BPA, causes increased inflammation in fat tissues after birth, which can lead to obesity and metabolic syndrome. Results of the ...

BPA affects sex-based behavior in mice

May 28, 2013

(Medical Xpress)—Bisphenol A (BPA) is a common chemical found in household plastics. Previous studies on rodents show that BPA exposure is associated with problems with brain and behavioral development. ...

BPA linked to a common birth defect in boys

Jun 17, 2013

A new study links fetal exposure to a common chemical pollutant, bisphenol A (BPA), to defects of a testicular hormone in newborn boys with undescended testicles. The results, which were presented Monday at The Endocrine ...

BPA lowers male fertility: report

Jun 06, 2011

Daily exposure to a chemical that is prevalent in the human environment, bisphenol A (BPA), causes lowered fertility in male mice, according to the results of a new study that will be presented Saturday at The Endocrine Society's ...

BPA exposure effects may last for generations

Jun 15, 2012

Exposure to low doses of Bisphenol A (BPA) during gestation had immediate and long-lasting, trans-generational effects on the brain and social behaviors in mice, according to a recent study accepted for publication in the ...

Recommended for you

Hospital logs staggering 2.5 million alarms in just a month

12 hours ago

Following the study of a hospital that logged more than 2.5 million patient monitoring alarms in just one month, researchers at UC San Francisco have, for the first time, comprehensively defined the detailed causes as well ...

User comments