Genetic risk score linked to increased risk of diabetes

July 30, 2013
Genetic risk score linked to increased risk of diabetes
A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according to a study published online July 8 in Diabetes.

(HealthDay)—A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according to a study published online July 8 in Diabetes.

Ehm A. Andersson, from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen in Denmark, and colleagues genotyped 5,850 individuals for 46 variants associated with type 2 diabetes. The team performed physical examinations and glucose tolerance tests at baseline and after five years.

During a median follow-up of 11 years, the researchers recorded 327 incident cases of type 2 diabetes. Each risk allele was associated with an increased risk of type 2 diabetes (hazard ratio, 1.06 per risk allele). After five years, while the general population improved their , each additional allele in the genetic risk score was associated with a relative increase in plasma glucose at fasting and during an and a relative decline in beta-cell function, with no effect on measures of insulin sensitivity.

"In conclusion, a genetic based on 46 variants associated strongly with incident type 2 diabetes and five-year changes in plasma glucose and beta-cell function," Andersson and colleagues write. "Individuals who gain weight may be more susceptible to the cumulative impact of type 2 diabetes risk variants on fasting ."

Explore further: Key variables examined in gestational diabetes advance

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Key variables examined in gestational diabetes advance

March 18, 2013

(HealthDay)—For women with gestational diabetes mellitus (GDM), clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus (T2DM), according to ...

New clues in hunt for heredity in type 2 diabetes

March 19, 2013

Type 2 diabetes has strong hereditary tendencies and the genes we are born with cannot be changed. However, new research from Lund University in Sweden shows that we can modify the function of the genes through the epigenetic ...

Gene variants link to insulin resistance based on diet

April 28, 2013

(HealthDay)—Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in ...

Recommended for you

Engineered hot fat implants reduce weight gain in mice

August 20, 2015

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose ...

Promising progress for new treatment of type 1 diabetes

July 30, 2015

New research from Uppsala University shows promising progress in the use of anti-inflammatory cytokine for treatment of type 1 diabetes. The study, published in the open access journal Scientific Reports, reveals that administration ...

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.