Genetic risk score linked to increased risk of diabetes

Genetic risk score linked to increased risk of diabetes
A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according to a study published online July 8 in Diabetes.

(HealthDay)—A genetic risk score based on 46 gene variants linked to type 2 diabetes is associated with increases in the risk of type 2 diabetes and declines in glucose control and beta-cell function, according to a study published online July 8 in Diabetes.

Ehm A. Andersson, from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen in Denmark, and colleagues genotyped 5,850 individuals for 46 variants associated with type 2 diabetes. The team performed physical examinations and glucose tolerance tests at baseline and after five years.

During a median follow-up of 11 years, the researchers recorded 327 incident cases of type 2 diabetes. Each risk allele was associated with an increased risk of type 2 diabetes (hazard ratio, 1.06 per risk allele). After five years, while the general population improved their , each additional allele in the genetic risk score was associated with a relative increase in plasma glucose at fasting and during an and a relative decline in beta-cell function, with no effect on measures of insulin sensitivity.

"In conclusion, a genetic based on 46 variants associated strongly with incident type 2 diabetes and five-year changes in plasma glucose and beta-cell function," Andersson and colleagues write. "Individuals who gain weight may be more susceptible to the cumulative impact of type 2 diabetes risk variants on fasting ."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Gene variants link to insulin resistance based on diet

Apr 28, 2013

(HealthDay)—Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online ...

Key variables examined in gestational diabetes advance

Mar 18, 2013

(HealthDay)—For women with gestational diabetes mellitus (GDM), clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus (T2DM), ...

Recommended for you

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments