Estrone levels predict incident type 2 diabetes in men

Estrone levels predict incident type 2 diabetes in men
Levels of estrone are associated with increased risk of incident type 2 diabetes in a cohort of community-dwelling men, according to a study published online May 20 in Diabetes Care.

(HealthDay)—Levels of estrone are associated with increased risk of incident type 2 diabetes in a cohort of community-dwelling men, according to a study published online May 20 in Diabetes Care.

Guneet Kaur Jasuja, Ph.D., from Boston University, and colleagues examined the correlation between circulating estradiol and estrone levels and diabetes risk for 1,458 men participating in the generation 2. Correlations between at examination 7 (1998 to 2001) and incident diabetes at examination 8 (6.8 years later) were assessed prospectively. Fasting glucose >125 mg/dL, medication use, or both were used to define .

The researchers found that, per cross-sectional doubling of estrone and estradiol levels, men with raised estrone and estradiol had 40 and 62 percent increased likelihoods of existing diabetes, respectively. At examination 7, free estrone was significantly associated with impaired fasting glucose (cross-sectional odds ratio, 1.28). With increasing quartiles of total and free estrone and estradiol there was an increase in risk for existing diabetes, and increasing quartiles of estrone levels were associated with an increase in risk of incident diabetes. In multivariate longitudinal analyses, a two-fold increase in total or free estrone levels at examination 7 correlated with 77 and 93 percent increases, respectively, in the odds of incident diabetes at examination 8.

"Although both estradiol and estrone exhibit cross-sectional associations with diabetes in men, in longitudinal analyses estrone is a more sensitive marker of than estradiol," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Journal information: Diabetes Care

Health News Copyright © 2013 HealthDay. All rights reserved.

Citation: Estrone levels predict incident type 2 diabetes in men (2013, June 10) retrieved 28 March 2024 from https://medicalxpress.com/news/2013-06-estrone-incident-diabetes-men.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Timing, duration of obesity impact adult diabetes risk

 shares

Feedback to editors