Kidney involvement, high anti-dsDNA predict lupus flares

Kidney involvement, high anti-dsDNA predict lupus flares
Kidney involvement and high anti-double stranded DNA are independent predictors of moderate-severe lupus flare, according to research published online June 10 in Arthritis & Rheumatism.

(HealthDay)—Kidney involvement and high anti-double stranded (ds) DNA are independent predictors of moderate-severe lupus flare, according to research published online June 10 in Arthritis & Rheumatism.

Michelle A. Petri, M.D., from Johns Hopkins University in Baltimore, and colleagues conducted post-hoc analysis to assess baseline demographics, , and biomarkers in 562 patients, treated with standard therapy alone, with and without flare at treatment weeks 24/52. Severe and moderate flares were defined using the modified SLE Flare Index (SFI) and the new British Isles Lupus Assessment Group (BILAG) A/B scores.

The researchers found that over 52 weeks the frequencies of SFI, BILAG 1A, and BILAG 1A/2B flares were 24, 23, and 32 percent, respectively. Using all three indices, in univariate analyses, predictors of flares at weeks 24/52 included: Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) ?12, anti-dsDNA positivity and proteinuria (?0.5 g/24 hours); BILAG renal, vasculitic, and hematologic scores; increased C-reactive protein; and B-lymphocyte stimulator (BLyS) ?2 ng/mL. In multivariate analysis, independent predictors at week 52 included: SELENA-SLEDAI/BILAG renal involvement and anti-dsDNA ?200 IU/mL (all three indices); SELENA-SLEDAI/BILAG neurologic and vasculitic involvement (BILAG A/2 B or 1A scores); BLyS ?2 ng/mL (SFI and BILAG 1A/2B scores); and low complement 3 (SFI).

"In summary, anti-dsDNA ?200 IU/mL and renal organ involvement at baseline were independent predictors of moderate-severe SLE flare at week 52 on all three flare indices," the authors write. "Close monitoring of patients with disease activity or biomarkers predictive of SLE flare may improve their care and long-term outcomes."

Several authors disclosed financial ties to GlaxoSmithKline and Human Genome Sciences, which supported the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

NY and NJ say they will require Ebola quarantines

10 hours ago

The governors of New Jersey and New York on Friday ordered a mandatory, 21-day quarantine for all doctors and other arriving travelers who have had contact with Ebola victims in West Africa.

WHO: Mali case may have infected many people

15 hours ago

The World Health Organization says a toddler who brought Ebola to Mali was bleeding from her nose during her journey on public transport and may have infected many people.

Two US nurses are declared cured of Ebola

16 hours ago

Two American nurses were declared cured of Ebola on Friday, and one was healthy enough to leave the hospital and meet President Barack Obama for a hug.

User comments