Alzheimer disease and Parkinson disease do not appear to share common genetic risk

A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).

Data sets from the United Kingdom, Germany, France and the United States were used to perform a combined genome-wide association analysis (GWA). The GWA study of AD included 3,177 patients with AD and 7,277 control patients, and the GWA analysis for PD included 5,333 patients with PD and 12,298 control patients. The gene-based analyses resulted in no significant evidence that supported the presence of loci (location of gene) that were associated with increased risk for both PD and AD, according to the study results.

"Our findings therefore imply that loci that increase the risk of both PD and AD are not widespread and that the pathological overlap could instead be 'downstream' of the primary that increase the risk of each disease," the study concludes.

More information: JAMA Neurol. Published online August 5, 2013. doi:10.1001/.jamaneurol.2013.448

Related Stories

Five CSF markers differentiate dementia, parkinsonism

Aug 28, 2012

(HealthDay)—Levels of five different cerebrospinal fluid (CSF) biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. ...

Diabetes drug tested in Parkinson's disease patients

May 20, 2013

Parkinson's disease (PD) is a degenerative neurological disorder marked by a progressive loss of motor control. Despite intensive research, there are currently no approved therapies that have been demonstrated to alter the ...

Recommended for you

Gait and dementia link confirmed

19 hours ago

Researchers at Newcastle University have found a definitive link between gait - the way someone walks - and early changes in cognitive function in people with Parkinson's disease.

Parkinson's disease may start in the gut

Oct 14, 2014

Parkinson's disease is strongly linked to the degeneration of the brain's movement center. In the last decade, the question of where the disease begins has led researchers to a different part of the human anatomy. In 2003, ...

User comments