Engineered rice protects against rotavirus infection

For children and immune compromised adults in developing countries, diarrheal disease induced by rotavirus can be life threatening. Current rotaviral vaccines are highly effective in the Western world, but are not as effective in developing countries. Additionally, these vaccines are not appropriate for use outside of a very narrow age window or in immune compromised individuals.

In the current issue of the Journal of Clinical Investigation Yoshikazu Yuki and colleagues at the University of Tokyo report the development of a strain of rice that produces a rotavirus-specific antibody. Both normal and immune deficient mice fed the engineered rice were protected against rotavirus. The researchers also report that the rice maintains its efficacy even after long-term storage and heat exposure.

This study provides a low cost, efficient strategy for prevention of rotavirus infection.

More information: Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection, J Clin Invest. DOI: 10.1172/JCI70266

add to favorites email to friend print save as pdf

Related Stories

Rotavirus vaccine given to newborns in Africa is effective

Jun 17, 2013

Mayo Clinic and other researchers have shown that a vaccine given to newborns is at least 60 percent effective against rotavirus in Ghana. Rotavirus causes fever, vomiting and diarrhea, which in infants can cause severe dehydration. ...

Developing new oral rotavirus vaccine

Mar 26, 2012

The University of Otago is playing a major role in the international development of a new low-cost oral vaccine to protect newborn babies against rotavirus.

India announces low-cost rotavirus vaccine (Update)

May 14, 2013

The Indian government announced Tuesday the development of a new low-cost vaccine proven effective against a diarrhea-causing virus that is one of the leading causes of childhood deaths across the developing world.

Waging war against rotavirus

Apr 10, 2012

Canada should show leadership in supporting adoption of the rotavirus vaccination in developing countries, but it must also ensure that all Canadian infants are vaccinated against the virus, states an editorial in CMAJ (Canadian Me ...

Recommended for you

Where Ebola battles are won

19 minutes ago

(HealthDay)—Four hospitals that are home to advanced biocontainment facilities have become America's ground zero in the treatment of Ebola patients.

Depression tied to worse lumbar spine surgery outcomes

2 hours ago

(HealthDay)—Depressive symptoms are associated with poorer long-term outcome in patients undergoing surgery for lumbar spinal stenosis (LSS), according to research published in the Oct. 1 issue of The Sp ...

Ebola death toll edging to 4,900 mark: WHO

3 hours ago

The death toll in the world's worst-ever Ebola outbreak has edged closer to 4,900, while almost 10,000 people have now been infected, new figures from the World Health Organization showed Wednesday.

US to track everyone coming from Ebola nations

3 hours ago

U.S. authorities said Wednesday that everyone traveling into the U.S. from Ebola-stricken nations will be monitored for symptoms for 21 days. That includes returning American aid workers, federal health employees ...

User comments