Engineered rice protects against rotavirus infection

For children and immune compromised adults in developing countries, diarrheal disease induced by rotavirus can be life threatening. Current rotaviral vaccines are highly effective in the Western world, but are not as effective in developing countries. Additionally, these vaccines are not appropriate for use outside of a very narrow age window or in immune compromised individuals.

In the current issue of the Journal of Clinical Investigation Yoshikazu Yuki and colleagues at the University of Tokyo report the development of a strain of rice that produces a rotavirus-specific antibody. Both normal and immune deficient mice fed the engineered rice were protected against rotavirus. The researchers also report that the rice maintains its efficacy even after long-term storage and heat exposure.

This study provides a low cost, efficient strategy for prevention of rotavirus infection.

More information: Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection, J Clin Invest. DOI: 10.1172/JCI70266

add to favorites email to friend print save as pdf

Related Stories

Rotavirus vaccine given to newborns in Africa is effective

Jun 17, 2013

Mayo Clinic and other researchers have shown that a vaccine given to newborns is at least 60 percent effective against rotavirus in Ghana. Rotavirus causes fever, vomiting and diarrhea, which in infants can cause severe dehydration. ...

Developing new oral rotavirus vaccine

Mar 26, 2012

The University of Otago is playing a major role in the international development of a new low-cost oral vaccine to protect newborn babies against rotavirus.

India announces low-cost rotavirus vaccine (Update)

May 14, 2013

The Indian government announced Tuesday the development of a new low-cost vaccine proven effective against a diarrhea-causing virus that is one of the leading causes of childhood deaths across the developing world.

Waging war against rotavirus

Apr 10, 2012

Canada should show leadership in supporting adoption of the rotavirus vaccination in developing countries, but it must also ensure that all Canadian infants are vaccinated against the virus, states an editorial in CMAJ (Canadian Me ...

Recommended for you

Listeria screening in public lavatories in Vienna

1 hour ago

Vienna's public lavatories were at the focus of a study by the Global Food Safety research group at the Vetmeduni Vienna. The researchers studied 224 public restrooms in Vienna, which are about 91 percent ...

Women with endometriosis need support, not judgement

3 hours ago

Known for years as the "career woman's disease" based on the idea that women without children develop disease in their reproductive organs, endometriosis is a painful condition thought to affect one in ten wome ...

Global Ebola conference seeks end to W.Africa outbreak

8 hours ago

Leaders of Ebola-hit countries in west Africa will attend an international conference in Brussels Tuesday to mobilise a final push to end the outbreak and ensure the delivery of nearly $5 billion in aid pledges.

High prevalence of HCV in baby boomers presenting to ER

18 hours ago

(HealthDay)—The prevalence of unrecognized chronic hepatitis C virus (HCV) is high among baby boomers presenting to the emergency department, according to a study published online Jan. 28 in Hepatology.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.