Heart disease risk appears associated with breast cancer radiation

Among patients with early stages of breast cancer, those whose hearts were more directly irradiated with radiation treatments on the left side in a facing-up position had higher risk of heart disease, according to research letter to JAMA Internal Medicine by David J. Brenner, Ph.D, D.Sc, of Columbia University Medical Center, New York, and colleagues.

Several reports have suggested links between radiation and long-term cardiovascular-related deaths, according to the study background.

Researchers examined the radiation treatment plans of 48 patients with stage 0 through IIA breast cancer who were treated after 2005 at the New York University Department of Radiation Oncology. They calculated the association between factors, such as mean cardiac dose, , treatment side, body positioning and coronary events.

According to study results, the highest coronary risks were seen for left-sided treatment in women of high baseline risk treated in the supine (lying down, head facing up) position. The lowest risks were for right-sided treatment in low-baseline risk women. In left-sided radiation, prone (lying down, facing down) position reduces cardiac doses and risks, while body positioning has little effect in right-sided therapy (where the heart is always out of field).

"Because the effects of radiation exposure on cardiac disease seem to be multiplicative, the highest absolute risks correspond to the highest baseline cardiac risk," the authors conclude. "Consequently, radiotherapy-induced risks of major coronary events are likely to be reduced in these patients by targeting baseline cardiac risk factors (cholesterol, smoking, hypertension), by lifestyle modification, and/or by pharmacological treatment."

More information: JAMA Intern Med. Published online October 28, 2013. DOI: 10.1001/jamainternmed.2013.11790

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Most seniors eligible for statin Rx under new guidelines

23 hours ago

(HealthDay)—Most older Americans qualify for treatment with statins under new guidelines for the treatment of blood cholesterol released late last year by the American College of Cardiology and the American ...

Asymptomatic atherosclerosis linked to cognitive impairment

Nov 25, 2014

In a study of nearly 2,000 adults, researchers found that a buildup of plaque in the body's major arteries was associated with mild cognitive impairment. Results of the study conducted at the University of Texas (UT) Southwestern ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.