Testing technique could lengthen lifespan of dialysis patients

October 30, 2013

A new testing method can better detect potentially fatal hormone imbalances in patients with end-stage kidney disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

At the end of 2009, more than 871,000 Americans were being treated for end-stage renal disease, according to the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). These patients require dialysis or kidney transplants to stay alive. About 10 to 20 percent of patients with stage 5, or end-stage renal disease, die each year.

One key factor that contributes to the risk of death in this population is levels of parathyroid hormone, the hormone that makes calcium available in the blood for important body functions. When parathyroid are too low or too high, it raises the mortality risk for patients with end-stage renal disease.

"The current tests for parathyroid hormone levels overlook a key factor," said the study's lead author, Berthod Hocher, MD, PhD, of the University of Potsdam in Potsdam-Rehbrücke, Germany. "When parathyroid hormone interacts with oxygen under conditions of stress such as end-stage , it becomes biologically inactive. Our new approach is the first to differentiate between non-oxidized, biologically active parathyroid hormone and oxidized parathyroid hormone. This will result in better monitoring and treatment for patients who have end-stage renal disease."

Researchers conducted a prospective cohort study to test this approach. The study authors monitored a group of 340 over the course of a five-year period. Researchers tested blood samples from the patients to determine their parathyroid hormone levels. During the course of the follow-up period, 170 participants died, many from cardiovascular disease, infections or cancer.

The patients who survived had higher median levels of non-oxidized parathyroid hormone than the study participants who died. The study found an increased rate of survival among dialysis who had the highest levels of non-oxidized parathyroid hormone.

"With more precise testing, health care professionals will have the information they need to improve clinical outcomes," Hocher said. "The nephrology community has long recognized there is an issue with current testing approaches, and now we can solve this problem and improve patient care."

More information: The article, "Non-Oxidized, Biologically Active Parathyroid Hormone Determines Mortality in Hemodialysis Patients," is scheduled to appear in the December 2013 issue of JCEM.

Related Stories

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.