Bedtime aspirin may reduce risk of morning heart attack

Taking aspirin at bedtime instead of in the morning might reduce acute heart events, according a new study presented at the American Heart Association's Scientific Sessions 2013.

Low-dose daily is recommended for people at high risk of heart disease and for reducing the risk of recurrent heart events. Aspirin thins the blood and makes it less likely to clot. The tendency for platelet activity to be higher peaks in the morning.

The Aspirin in Reduction of Tension II trial is the first study to explore the timing of aspirin intake among cardiovascular disease patients. In the randomized, open-label study, 290 patients took either 100 mg of aspirin upon waking or at bedtime during two 3-month periods. At the end of each period, and platelet activity was measured.

Blood pressure was not reduced; however, bedtime aspirin platelet activity was reduced by 22 units (aspirin reaction units).

"Because higher platelet activity contributes to a higher risk of acute heart events, this simple intervention – switching aspirin intake from morning to bedtime – could be beneficial for the millions of patients with who take aspirin on a daily basis," said Tobias Bonten, M.D., Ph.D student at the Leiden University Medical Center in the Netherlands.

add to favorites email to friend print save as pdf

Related Stories

Aspirin enhances platelet isoprostanes in type 2 diabetes

Mar 23, 2012

(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published ...

Dipyrone negates aspirin's antiplatelet effect

Aug 22, 2013

(HealthDay)—There is an unfavorable pharmacological drug interaction between the non-narcotic analgesic dipyrone and aspirin in patients with coronary artery disease (CAD), according to research published online Aug. 14 ...

Recommended for you

User comments