Bacterial toxin a potential trigger for multiple sclerosis

Researchers from Weill Cornell Medical College have added to the growing body of evidence that multiple sclerosis may be triggered by a toxin produced by common foodborne bacteria. The presented their research at the 2014 ASM Biodefense and Emerging Diseases Research Meeting.

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by blood brain (BBB) permeability and demyelination, a process in which the insulating myelin sheaths of neurons are damaged. The disease is thought to be triggered in a genetically susceptible individual by a combination of one or more environmental factors. The environmental trigger of MS, however, is still unknown. According to the National Multiple Sclerosis Society, the condition affects approximately 400,000 Americans and is, with the exception of trauma, the most frequent cause of neurological disability beginning in early to middle adulthood.

"We provide evidence that supports epsilon toxin's ability to cause BBB permeability and show that epsilon toxin kills the brain's myelin producing , oligodendrocytes; the same cells that die in MS lesions," says Jennifer Linden of Weill Cornell Medical College, who presented the research. "We also show that epsilon toxin targets other cells types associated with MS inflammation such as the retinal vascular and meningeal cells. Epsilon toxin may be responsible for triggering MS."

Epsilon toxin is produced by certain strains of Clostridium perfringens, a spore-forming bacterium that is one of the most common causes of in the United States. The U.S. Centers for Disease Control and Prevention estimates that non-epsilon toxin producing C. perfringens strains cause nearly a million cases of foodborne illness each year.

Previous studies have suggested that C. perfringens, and in particular epsilon toxin, may play a role in triggering MS. Late last year Linden and her colleagues discovered C. perfringens type B (a strain that is not known to infect humans and produces the epsilon toxin) in a 21-year-old woman who was experiencing a flare-up of her MS. To further test their hypothesis Linden and her colleagues studied the behavior of the toxin in mice, specifically which cells it targeted.

They discovered that the toxin did target the brain cells associated with MS pathology. But that was not all they found.

"Originally, we only thought that epsilon toxin would target the brain endothelium cells and oligodendrocytes; we just happened to notice that it also bound to and killed meningeal cells. This was exciting because it provides a possible explanation for meningeal inflammation and subpial cortical lesions exclusively observed in MS patients, but not fully understood," says Linden.

They also tested samples of local foods for the presence of C. perfringens and the toxin gene. Of the 37 food samples, 13.5% were positive for bacteria and 2.7% were positive for the epsilon toxin gene.

Linden says these findings are important, because if it can be confirmed that epsilon toxin is indeed a trigger of MS, development of a neutralizing antibody or vaccine directed against epsilon toxin might stop the progression of the disease or prevent it from even developing.

Related Stories

Engineered anti-toxin antibodies improve efficacy

Jan 09, 2014

The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of ...

Scientists describe how anthrax toxins cause illness, death

Aug 28, 2013

Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and the National Heart, Lung, and Blood Institute, both part of the National Institutes of Health, have identified the cells in two distinct ...

New cause identified for necrotic enteritis in chicken

Feb 08, 2008

Researchers from Monash University and CSIRO Livestock Industries have demonstrated for the first time that alpha-toxin protein, long thought to be required for necrotic enteritis to develop, is not the main cause of the ...

Recommended for you

Recorded Ebola deaths top 7,000

18 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

23 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.