Mice exposed to retinoid deficiency in utero exhibit bronchial hyperresponsiveness as adults

Individuals with asthma and COPD are subject to debilitating bronchospasm as a result of airways that are hyperresponsive to stimuli. Factors that lead to the development of airway hyperresponsiveness are not well characterized.

In this issue of the Journal of Clinical Investigation, Wellington Cardoso and colleagues at the Boston University School of Medicine reveal that mice born to mothers with retinoid deficiency during pregnancy are at increased risk of developing airway hyperesponsiveness. Prenatal retinoid deficiency promoted altered airway development and lung differentiation. Bronchial hyperresponsiveness and abnormal phenotypes persisted throughout the postnatal period regardless for vitamin A status in the adult.

These results suggest that retinoid signaling in the lung is important for proper airway development and prevention of inappropriate pulmonary inflammatory responses.

More information: Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice, J Clin Invest. DOI: 10.1172/JCI70291

add to favorites email to friend print save as pdf

Related Stories

Researchers explore PKC role in lung disease

Feb 25, 2013

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

Tweaking gene expression to repair lungs

Feb 25, 2013

A healthy lung has some capacity to regenerate itself like the liver. In COPD, these reparative mechanisms fail. HDAC therapies may be useful for COPD, as well as other airway diseases. The levels of HDAC2 ...

Recommended for you

Sierra Leone reaches final day of Ebola lockdown

11 minutes ago

Frustrated residents complained of food shortages in some neighborhoods of Sierra Leone's capital on Sunday as the country reached the third and final day of a sweeping, unprecedented lockdown designed to ...

Sierra Leone faces criticism over Ebola shutdown

Sep 20, 2014

Sierra Leone began the second day of a 72-hour nationwide shutdown aimed at containing the spread of the deadly Ebola virus on Saturday amid criticism that the action was a poorly planned publicity stunt.

Presence of peers ups health workers' hand hygiene

Sep 19, 2014

(HealthDay)—The presence of other health care workers improves hand hygiene adherence, according to a study published in the October issue of Infection Control and Hospital Epidemiology.

Sierra Leone streets deserted as shutdown begins

Sep 19, 2014

Sierra Leone's normally chaotic capital resembled a ghost town on Friday as residents were confined to their homes for the start of a three-day lockdown aimed at halting the deadly Ebola epidemic.

User comments