Mice exposed to retinoid deficiency in utero exhibit bronchial hyperresponsiveness as adults

Individuals with asthma and COPD are subject to debilitating bronchospasm as a result of airways that are hyperresponsive to stimuli. Factors that lead to the development of airway hyperresponsiveness are not well characterized.

In this issue of the Journal of Clinical Investigation, Wellington Cardoso and colleagues at the Boston University School of Medicine reveal that mice born to mothers with retinoid deficiency during pregnancy are at increased risk of developing airway hyperesponsiveness. Prenatal retinoid deficiency promoted altered airway development and lung differentiation. Bronchial hyperresponsiveness and abnormal phenotypes persisted throughout the postnatal period regardless for vitamin A status in the adult.

These results suggest that retinoid signaling in the lung is important for proper airway development and prevention of inappropriate pulmonary inflammatory responses.

More information: Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice, J Clin Invest. DOI: 10.1172/JCI70291

Related Stories

Researchers explore PKC role in lung disease

date Feb 25, 2013

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

Tweaking gene expression to repair lungs

date Feb 25, 2013

A healthy lung has some capacity to regenerate itself like the liver. In COPD, these reparative mechanisms fail. HDAC therapies may be useful for COPD, as well as other airway diseases. The levels of HDAC2 ...

Recommended for you

Fighting back against superbugs

date 4 minutes ago

Antibiotics—and antibiotic resistance—are in the news once again, with announcements by McDonald's and Costco that they will eliminate antibiotics that are important to human medicine from use in the ...

Harnessing the power of microbes as therapeutics

date 1 hour ago

A new report recently released by the American Academy of Microbiology discusses how specific microbes can be modified to enhance their therapeutic potential for treating human diseases such as cancer and antibiotic resistant ...

New genetic link found for alcohol-related liver cirrhosis

date 1 hour ago

In most people, any liver damage that might occur from drinking alcohol is reversible. However, in 25 to 30 percent of alcoholics what begins as accumulation of fat in the liver progresses to inflammation, fibrosis and ultimately ...

Could camel antibodies protect humans from MERS?

date 1 hour ago

Antibodies from dromedary camels protected uninfected mice from Middle East Respiratory Syndrome (MERS), and helped infected mice expunge the disease, according to a study published online March 18th in the ...

Sierra Leone ends anti-Ebola lockdown after three days

date 5 hours ago

Sierra Leoneans were once again allowed to leave their homes Sunday evening after the government announced the end of a three-day nationwide lockdown aimed at preventing a resurgence of the deadly Ebola virus.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.