Bone development of the unborn young rats of obese mothers impaired

by Marcia Wood
ARS-funded researcher Jin-Ran Chen has shown that bone development of unborn young of mother lab rats (dams) fed high-fat rations to induce obesity was significantly impaired when compared to bones of fetal young of dams that were given lower-fat rations.

Does obesity during pregnancy impact the baby's chances of developing strong, healthy bones? No one knows for certain, but ongoing U.S. Department of Agriculture (USDA)-funded studies at the Arkansas Children's Nutrition Center in Little Rock are helping to provide clues.

In an early investigation, Jin-Ran Chen, a principal investigator with the center's Skeletal Development Laboratory, showed that bone development of the unborn young of mother lab rats (dams) fed high-fat rations to induce obesity was significantly impaired, in contrast to the bones of the fetal young of dams that were given lower-fat rations.

Analysis of fetal bone cells from the skull and vertebrae suggests that changes in the functioning of a gene, HoxA10, may help explain this difference in early bone formation, according to Chen.

Studies by scientists elsewhere have already established that HoxA10 is important to and growth. But Chen's investigation, documented in a 2012 article in the Federation of American Societies for Experimental Biology's FASEB Journal, is apparently the first to suggest that , induced by the high-fat regimen, may turn off or "downregulate" this gene, thus suppressing robust .

Chen and his team found that HoxA10 was downregulated as a result of high levels of DNA methylation, a biochemical process also referred to as gene methylation. If the results seen in rats hold true for humans, elevated DNA methylation of HoxA10 may increase the baby's risk of developing , such as osteoporosis, later in life.

The results also suggest that it is critical to start early in ensuring that a mother's nutrition benefits the developing child's .

add to favorites email to friend print save as pdf

Related Stories

Blueberries help lab rats build strong bones

Jun 21, 2011

Compounds in blueberries might turn out to have a powerful effect on formation of strong, healthy bones, if results from studies with laboratory rats turn out to hold true for humans.

Ongoing research analyzes formulas, mother's milk

Jan 20, 2012

Soy-based baby formula nourishes millions of America's infants. Now, U.S. Department of Agriculture (USDA)-funded scientist Jin-Ran Chen is taking a close look at the effects that soy formula, cow's-milk formula, ...

Recommended for you

Stem cells faulty in Duchenne muscular dystrophy

11 hours ago

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have ...

Here's how the prion protein protects us

16 hours ago

The cellular prion protein (PrPC) has the ability to protect the brain's neurons. Although scientists have known about this protective physiological function for some time, they were lacking detailed knowledge ...

Regulation of maternal miRNAs in early embryos revealed

17 hours ago

The Center for RNA Research at the Institute for Basic Science (IBS) has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.