HPV vaccination is associated with reduced risk of cervical lesions in Denmark

A reduced risk of cervical lesions among Danish girls and women at the population level is associated with use of a quadrivalent HPV vaccine after only six years, according to a new study published February 19 in the Journal of the National Cancer Institute.

Two HPV vaccines are currently available and have proven to be highly effective against HPV16/18-associated cervical cancer. One of these vaccines, a quadrivalent vaccine, was licensed in Denmark in 2006, and it was subsequently incorporated into general childhood vaccination programs for girls free of charge and was made available to girls and women and to boys and men not covered by the program for a fee. To date, a nationwide population-based study of HPV-related cervical abnormalities in vaccinated vs unvaccinated women based on information on vaccination status at the individual level has not been reported.

Susanne Krüger Kjaer, MD, and her team from Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center in Copenhagen, Denmark, and colleagues identified all girls and women born in Denmark in 1989-1999 and obtained the corresponding HPV in 2006-2012 for each individual, as well as information on incident cases of among those in the cohort. Risk of cervical atypia (abnormal cervical cells) or worse (atypia+) and grade 2 or 3 (CIN2/3) were statistically significantly reduced among vaccinated women born between 1991 and 1994 vs unvaccinated women. Among women born between 1989 and 1990, a statistically significant of atypia+ was observed for vaccinated vs unvaccinated women; similar results were observed for CIN2/3 but these findings did not reach statistical significance. Furthermore, no cervical lesions were reported among girls born between 1997 and 1999.

The authors write, "In conclusion, our results show that vaccination with the quadrivalent HPV vaccine is already effective in reducing the risk for cervical precursor lesions at among young women in Denmark."

Related Stories

Three doses of HPV vaccine recommended against genital warts

date Feb 11, 2014

Two doses of vaccine against human papillomavirus (HPV) provide good protection against genital warts, but three doses is better according to an extensive register study by researchers at Karolinska Institutet in Sweden. ...

Recommended for you

Spicy treatment the answer to aggressive cancer?

date 1 hour ago

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

date 18 hours ago

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

date 18 hours ago

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.