Fresh hope for preventing pneumonia in the elderly

by Susi Hamilton

There are calls for the frail and elderly not be be overlooked for vaccines against pneumonia this winter, with UNSW research challenging conventional wisdom on immunisation effectiveness in older patients.

In a novel finding, the UNSW-led research demonstrated that even older, frail with low baseline immunity are able to generate a significant response to pneumococcal vaccines.

Pneumonia is one of Australia's leading causes of death, ranking in the top 20 in 2012 and is more common in winter. It is especially dangerous in young children and the elderly. In high-risk groups such as the hospitalised frail elderly, mortality is greater than 50 percent.

Previous work* has shown that the frail elderly are significantly less likely to be offered vaccines than other patients – those older than 80 are 30 percent less likely to be immunised and dementia patients are 70 percent less likely. This may be because doctors are not confident such patients can mount a sufficient immune response to vaccines.

But a examining two different (23vPPV and PCV7) in frail hospitalised elderly found that both can elicit a robust reaction from those with low baseline immunity and there is a greater and more sustained response when the two vaccines are used together, in sequence.

"This study offers hope for novel combinations of the old and new vaccines for prevention of pneumococcal disease in this vulnerable group," says Professor MacIntyre, the head of UNSW's School of Public Health and Community Medicine.

The finding, published in PLoS One, is an important discovery given those with the lowest immunity are at greatest risk of developing invasive pneumococcal disease—the most common bacterial cause of – and shows there is a case for vaccinating .

As well as pneumonia, (an infection with the bacterium Streptococcus pneumoniae) can cause middle ear and sinus infections, meningitis and septicaemia. The majority of deaths occur in those aged 65 or older, and most cases are preventable by vaccination.

"Vaccination against preventable diseases is low-hanging fruit as a strategy for healthy ageing, and no should be denied vaccination simply because immunity wanes with age," says Professor MacIntyre.

More information: MacIntyre CR, Ridda I, Gao Z, Moa AM, McIntyre PB, et al. (2014) "A Randomized Clinical Trial of the Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine Compared to 23-Valent Polysaccharide Vaccine in Frail, Hospitalized Elderly." PLoS ONE 9(4): e94578. DOI: 10.1371/journal.pone.0094578

Ridda I, et al. "Predictors of pneumococcal vaccination uptake in hospitalized patients aged 65 years and over shortly following the commencement of a publicly funded national pneumococcal vaccination program in Australia." Hum Vaccin. 2007 May-Jun;3(3):83-6. Epub 2007 May 30.

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