Enhancing the immune response through next generation polymeric vaccine adjuvants

The easily modifiable properties of polymers and their potential for functionalization, shown in blue and red respectively, make them attractive candidates for replacing conventional adjuvants. Credit: Technology journal

Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens. Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

The great success of vaccines over the past two centuries as a has led to a significant reduction in morbidity and death caused by controllable infectious diseases. The effectiveness of vaccines is dependent on their ability to induce a protective immune response in recipients. Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to patho-gens. Adjuvants are especially necessary to boost the for subunit vac-cines. However, conventional are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic. In addition to a comprehensive study of their use in vaccines, this article sum-marizes the benefits and challenges associated with the use of these polymer systems as adjuvants.

More information: www.worldscientific.com/doi/pd… 42/S2339547814300017

add to favorites email to friend print save as pdf

Related Stories

Vaccine adjuvant uses host DNA to boost pathogen recognition

Apr 05, 2013

Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective. No one knows, however, how they boost the immune response. In the March 19, 2013, issue of the Proceedings of ...

Adjuvant combo shows potential for universal influenza vaccine

Jun 08, 2011

Researchers at National Jewish Health have discovered how to prime a second arm of the immune system to potentially boost influenza vaccine effectiveness. A combination of two adjuvants, chemicals used to boost the effectiveness ...

Research describes advantages of new vaccine adjuvant

Dec 12, 2011

New research from the laboratory of Dr. Elizabeth Leadbetter at the Trudeau Institute may lead to a whole new class of vaccines. Dr. Leadbetter's lab has discovered new properties of a potential vaccine adjuvant that suggest ...

Recommended for you

Commensal bacteria help orchestrate immune response in lung

Sep 11, 2014

Studies in mice demonstrate that signals from the bacteria that harmlessly—and often beneficially—inhabit the human gastrointestinal tract boost the immune system's ability to kill a major respiratory pathogen, Klebsiella pn ...

How age alters our immune response to bereavement

Sep 09, 2014

Young people have a more robust immune response to the loss of a loved one, according to new research from the University of Birmingham, providing insight into how different generations cope with loss.

User comments