Prenatal risk factors may put children at risk of developing kidney disease

April 17, 2014

Certain prenatal risk factors are associated with the development of chronic kidney disease in children, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). Future studies should investigate whether modifying these factors could help protect children's kidney health.

Risks for certain types of kidney disease may arise before birth, and researchers suspect that the development of (CKD) may be programmed prenatally. Christine Hsu, MD (University of Washington) and her colleagues sought to determine the association of childhood CKD with prenatal risk factors, including birth weight, maternal diabetes, and maternal overweight/obesity.

The researchers studied 1994 patients with childhood CKD and 20,032 controls without the disease, and the team linked maternal and infant characteristics in birth records from 1987 to 2008 to .

The prevalence of CKD was 126.7 cases per 100,000 births. Infants with were nearly three times more likely to develop childhood CKD than infants with normal . Infants were also at increased risk if their mothers developed diabetes during pregnancy of if their mothers were overweight or obese.

"We hope this research leads to further research on ways to reduce kidney disease through either early treatment or prevention that might begin even before birth," said Dr. Hsu. "Previous studies show that of maternal diabetes significantly reduces the risk of congenital malformations in children. We hope our work leads to future studies to investigate whether strict control of maternal diabetes and/or reducing maternal obesity/overweight reduces childhood CKD."

Explore further: Kidney disease progresses faster in African Americans than other races

More information: The article, entitled "Prenatal Risk Factors for Childhood CKD," will appear online at on April 17, 2014.

Related Stories

Nonalcoholic fatty liver disease linked to CKD in T1DM

April 9, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published online April 2 in ...

Recommended for you

Monkeys in Asia harbor virus from humans, other species

November 19, 2015

When it comes to spreading viruses, bats are thought to be among the worst. Now a new study of nearly 900 nonhuman primates in Bangladesh and Cambodia shows that macaques harbor more diverse astroviruses, which can cause ...

One-step test for hepatitis C virus infection developed

November 14, 2015

UC Irvine Health researchers have developed a cost-effective one-step test that screens, detects and confirms hepatitis C virus (HCV) infections. Dr. Ke-Qin Hu, director of hepatology services, will present findings at the ...

Computer model reveals deadly route of Ebola outbreak

November 10, 2015

Using a novel statistical model, a research team led by Columbia University's Mailman School of Public Health mapped the spread of the 2014-2015 Ebola outbreak in Sierra Leone, providing the most detailed picture to date ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.