ATS: AMG 157 offers relief for allergen-induced asthma

ATS: AMG 157 offers relief for allergen-induced asthma

(HealthDay)—Twelve weeks of the novel AMG 157 antibody treatment may benefit patients with poorly controlled asthma, according to a study published online May 20 in the New England Journal of Medicine. This research was published to coincide with the annual meeting of the American Thoracic Society, held from May 16 to 21 in San Diego.

Gail M. Gauvreau, Ph.D., from McMaster University in Hamilton, Canada, and colleagues randomized 31 patients with mild allergies to receive three monthly doses of AMG 157 (700 mg) or placebo intravenously. Allergen challenges were conducted on days 42 and 84. Maximum percentage decrease in the forced expiratory volume in one second (FEV1) was measured.

The researchers found that AMG 157 cut most measures of allergen-induced early and late asthmatic responses. Compared to the , during the late response, FEV1 was 34 percent smaller in the AMG-157 group on day 42 (P = 0.09) and 45.9 percent smaller on day 84 (P = 0.02). There were also significant decreases in levels of blood and sputum eosinophils before and after the allergen challenge with AMG 157. There were no serious adverse events reported.

"Treatment with AMG 157 reduced allergen-induced bronchoconstriction and indexes of airway inflammation before and after allergen challenge," the authors write.

The study was funded by Amgen, the manufacturer of AMG 157.

More information: Abstract
Full Text
Editorial
More Information

add to favorites email to friend print save as pdf

Related Stories

New drug significantly lowers bad cholesterol

Nov 06, 2012

For many people with high cholesterol, statins serve as the first line of treatment. However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" ...

Monthly shot lowers cholesterol 66 percent: study

Mar 26, 2012

A monthly injection of an experimental drug made by the US biotech firm Amgen reduced patients' cholesterol by up to 66 percent, according to a small study described at a US cardiology conference.

Recommended for you

Ontario has one of the highest rates of IBD in the world

Aug 28, 2014

One in every 200 Ontarians has been diagnosed with inflammatory bowel disease (IBD), with the number of people living with the disease increasing by 64 per cent between 1999 and 2008, according to a study by researchers at ...

New drug promises relief for inflammatory pain

Aug 27, 2014

Pain from inflammation sidelines thousands of Americans each year. Many face a tough choice: deal with the pain, take a potentially addictive opioid or use a nonsteroidal anti-inflammatory drug that may increase risk for ...

Overweight causes hazardous inflammations

Aug 25, 2014

Researchers have found a possible molecular explanation for why overweight is harmful. This new knowledge may provide new drugs for heart attack, stroke, cancer and chronic intestinal inflammation.

Asthma outcomes worse in older women

Aug 21, 2014

(HealthDay)—Older women face increased challenges in managing their asthma, according to a review published in the August issue of the Annals of Allergy, Asthma & Immunology.

User comments