Grape skin extract may soon be answer to treating diabetes

The diabetes rate in the United States nearly doubled in the past 10 years. Approximately 26 million Americans are now classified as diabetic, stressing an urgent need for safe and effective complementary strategies to enhance the existing conventional treatment for diabetes.

Preliminary studies by researchers at Wayne State University have demonstrated that grape skin extract (GSE) exerts a novel inhibitory activity on hyperglycemia and could be developed and used to aid in . Recently funded by the National Center for Complementary and Alternative Medicine of the National Institutes of Health, this $2.1 million transitional study will provide insights into the novel inhibitory action of GSE on postprandial hyperglycemia and will also provide preclinical data in support of the biological effectiveness and safety of GSE and its components in potential prevention and treatment of .

"It is hopeful that our research may eventually lead to the successful development of a safe, targeted nutritional intervention to support and treatment," said Kequan Zhou, Ph.D., assistant professor of food and nutrition science in the College of Liberal Arts and Sciences, and lead investigator on the grant. "Our study will provide important pre-clinical data regarding the anti-diabetic mechanisms, biological efficacy and safety of GSE that should facilitate eventual translation into future clinical studies to assess GSE and its components as a safe, low-cost and evidence-based nutritional intervention for diabetes."

Type 2 diabetes is the most common form of diabetes. With type 2 diabetes, the body does not produce enough insulin or the cells ignore the insulin. In addition, some groups have a higher risk for developing type 2 diabetes, including African Americans, Latinos, Native Americans, Asian Americans/Pacific Islanders, and the elderly.

"Type 2 diabetes is one of the major chronic diseases of modern societies," said Gloria Heppner, Ph.D., associate vice president for research at Wayne State University. "It threatens the health of a variety of populations, with growing numbers of young people being diagnosed with the disease every day. Dr. Zhou's study offers great hope for a potential treatment that is natural and without harmful side effects for the many people inflicted with type 2 ."

add to favorites email to friend print save as pdf

Related Stories

Diabetes duration and severity associated with brain atrophy

Apr 29, 2014

Type 2 diabetes may be associated with brain degeneration, according to a new multicenter study published online in the journal Radiology. The study also found that, contrary to common clinical belief, diabetes may not be ...

Burden of diabetic ketoacidosis still unacceptably high

Mar 31, 2014

Diabetic ketoacidosis (DKA), a life-threatening but preventable condition, remains an important problem for youth with diabetes and their families. Diabetic ketoacidosis is due to a severe lack of insulin and it is often ...

Recommended for you

Screening for diabetes at dental visits using oral blood

Feb 26, 2015

It is estimated that 8.1 million of the 29.1 million Americans living with diabetes are undiagnosed and many who have diabetes have poor glycemic control. Given that each year many Americans visit a dental provider but not ...

CBT, sertraline insufficient in diabetes and depression

Feb 26, 2015

(HealthDay)—For patients with diabetes and depression, improvements in depression are seen with cognitive behavioral therapy (CBT) or sertraline, with a significant advantage for sertraline, but glycemic ...

Early signs in young children predict type 1 diabetes

Feb 26, 2015

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the ...

Daily menu plan reduces blood sugar significantly

Feb 25, 2015

A large group of people with diabetes who followed a menu plan created by University of Alberta nutrition researchers for just three months significantly reduced their blood sugar levels.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.