Patients with a certain form of kidney disease may have a reduced risk of cancer

May 22, 2014

Patients with a certain form of kidney disease may have a reduced risk of cancer compared with patients with other kidney diseases, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Polycystic kidney disease (PKD) is a passed down through families in which many cysts form in the kidneys, causing them to become enlarged. It's thought to have cancer-like features, but cancer risk has never been compared between PKD patients and others with . Cancer risk is also elevated in people who have received a kidney transplant, due to the immunosuppressive drugs they must take.

James B. Wetmore, MD, MS (University of Kansas Medical Center) and his colleagues conducted the first study to examine cancer risk in with PKD and to compare their risk to that of other kidney transplant recipients.

The team analyzed data from the National Cancer Institute's Transplant Cancer Match Study, which contains information on all solid in the United States, as well as data from 15 population-based US cancer registries. For PKD recipients, the investigators compared overall cancer risk to that in the general population. They also compared cancer incidence in PKD vs non-PKD kidney transplant recipients. The analysis included 10,166 kidney transplant recipients with PKD and 107,339 without.

After adjusting for demographic differences between kidney recipients with PKD and other recipients, PKD patients were 16% less likely to develop cancer than others who received a kidney transplant. Compared with the general population, overall cancer risk was increased 48% in PKD recipients, while the overall cancer risk in non-PKD recipients was increased 86%.

The findings indicate that PKD patients who received transplants do not have a higher risk of cancer than other kidney recipients. In fact, their may be lower. "The reason for the decreased risk is uncertain, but some factor or factors in PKD patients—either inherent in the disease process itself or related to the care PKD patients receive—is associated with lower risks of cancers," said Dr. Wetmore. "Further study is required to determine how PKD might influence the development of cancer."

Dr. Wetmore speculated that PKD may induce certain anti-neoplastic defense mechanisms that guard against the subsequent development of cancer. Alternatively, it may be that PKD patients, who are frequently aware that they have a progressive medical condition and who therefore typically receive close medical care for many years or decades, engage in other healthy behaviors that prevent cancer.

Explore further: Cancerous cells from donor kidney linked to recipient skin cancer

More information: The article, entitled "Polycystic Kidney Disease and Cancer after Renal Transplantation," will appear online at on May 22, 2014.

Related Stories

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.