Personalized fluid levels cuts acute kidney injury

Personalized fluid levels cuts acute kidney injury

(HealthDay)—A new fluid protocol is safe and effective in preventing contrast-induced acute kidney injury in patients undergoing cardiac catheterization, according to a study published in the May 24 issue of The Lancet.

Somjot S. Brar, M.D., from Kaiser Permanente in Los Angeles, and colleagues conducted a phase 3 trial involving 396 adult undergoing (with an estimated of ≤60 mL/min/1.73 m² and one or more of several risk factors). Patients were randomized (1:1) to either left ventricular end-diastolic pressure-guided volume expansion (196 participants) or a control group where they received a standard fluid administration protocol (200 participants).

The researchers found that contrast-induced acute kidney injury occurred less frequently in patients in the left ventricular end-diastolic pressure-guided group (6.7 percent versus 16.3 percent in the control group; relative risk, 0.41; P = 0.005). Shortness of breath occurred in three patients in each group, requiring hydration treatment to be prematurely terminated.

"Left ventricular end-diastolic pressure-guided fluid administration seems to be safe and effective in preventing contrast-induced in patients undergoing cardiac catheterization," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Recommended for you

Explainer: What is Chagas disease?

date 14 hours ago

According to an article in the Journal of the American Medical Association (JAMA), in a Los Angeles clinic treating patients with heart failure, about 20% of Latin American patients have Chagas disease. What is that?, y ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.