What what role does MSG play in obesity and fatty liver disease?

May 27, 2014
©2014, Mary Ann Liebert, Inc., publishers

The commonly used food additive monosodium glutamate (MSG) has been linked to obesity and disorders associated with the metabolic syndrome including progressive liver disease. A new study that identifies MSG as a critical factor in the initiation of obesity and shows that a restrictive diet cannot counteract this effect but can slow the progression of related liver disease is published in Journal of Medicinal Food.

Makoto Fujimoto and a team of international researchers from Japan, the U.S., and Italy monitored the weight gain and development of nonalcoholic fatty and its progression to in MSG-treated mice fed either a calorie-restricted or regular diet. They report their findings in the article "A Dietary Restriction Influences the Progression But Not the Initiation of MSG-Induced Nonalcoholic Steatohepatitis".

"Although MSG has been deemed a safe food additive, its dosage, interaction with other drugs, effects on vulnerable populations, and effects on and neurological diseases are unknown," says Co-Editor-in-Chief Sampath Parthasarathy, MBA, PhD, Florida Hospital Chair in Cardiovascular Sciences, University of Central Florida, Orlando, in the Editorial "How Safe is Monosodium Glutamate? Exploring the Link to Obesity, Metabolic Disorders, and Inflammatory Disease" . The findings by Fujimoto et al. "may have far reaching implications, as is a major problem across the globe."

Explore further: Weight-loss surgery can reduce liver damage

More information: The paper is available on the Journal of Medicinal Food website

Related Stories

Weight-loss surgery can reduce liver damage

May 4, 2014

Bariatric surgery, which is best known for its ability to help patients lose substantial weight, can also result in significant improvement in nonalcoholic fatty liver disease (NAFLD), according to new research presented ...

Sugar intake is not directly related to liver disease

November 1, 2013

Despite current beliefs, sugar intake is not directly associated with nonalcoholic fatty liver disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Rather, ...

Recommended for you

Yo-yo dieting might cause extra weight gain

December 5, 2016

Repeated dieting may lead to weight gain because the brain interprets the diets as short famines and urges the person to store more fat for future shortages, new research by the universities of Exeter and Bristol suggests.

New target receptor discovered in the fight against obesity

November 25, 2016

The team of scientists from King's College London and Imperial College London tested a high-fat diet, containing a fermentable carbohydrate, and a control diet on mice and looked at the effect on food intake of those with ...

Does where you live affect what you weigh?

November 21, 2016

Adult obesity rates in the United States have reached epidemic proportions, with one in four people considered obese. Yet, obesity rates vary considerably across states and counties.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.