Abbreviated protocol feasible in breast cancer MRI screening

Abbreviated protocol feasible in breast cancer MRI screening

(HealthDay)—An abbreviated protocol (AP) can accurately establish the absence of breast cancer and has diagnostic accuracy similar to that of a full diagnostic protocol (FDP) in breast magnetic resonance imaging (MRI) screening, according to a study published online June 23 in the Journal of Clinical Oncology.

Christiane K. Kuhl, M.D., from the University Hospital of Aachen in Germany, and colleagues conducted a prospective observational reader study in 443 women who underwent 606 screening MRIs. Radiologists searched for significant enhancement by reviewing the maximum-intensity projection (MIP) images. They then characterized enhancement and established diagnosis by reviewing the complete AP (first postcontrast subtracted and MIP images). The FDP was analyzed thereafter.

The researchers found that MRI acquisition time was 17 minutes for the FDP and three minutes for AP. The average time taken to read a single MIP was 2.8 seconds, and the complete AP took 28 seconds. Eleven breast cancers were diagnosed (additional cancer yield, 18.2 per 1,000), with MIP readings positive in 10 of these cancers (90.9 percent). MIP allowed establishment of the absence of in 418 of 419 cases (negative predictive value, 99.8 percent). All cancers were diagnosed with interpretation of the complete AP and FDP. The specificity and positive predictive values were equivalent for AP versus FDP (94.3 versus 93.9 percent and 24.4 versus 23.4 percent, respectively).

"With a reading time <30 seconds for the complete AP, diagnostic accuracy was equivalent to that of the FDP and resulted in an additional cancer yield of 18.2 per 1,000," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

add to favorites email to friend print save as pdf

Related Stories

Study examines BI-RADS and MRI in predicting breast cancer

May 15, 2012

A large, multicenter study found that the Breast Imaging and Reporting Data Systems (BI-RADS) terminology used by radiologists to classify breast imaging results is useful in predicting malignancy in breast lesions detected ...

Recommended for you

Decoding the emergence of metastatic cancer stem cells

13 hours ago

In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The research reveals a common pattern ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.