Engineered bacteria keep mice lean

Credit: Martha Sexton/public domain

Obesity levels are rising throughout the world. As obesity rates increase, so do the incidences of diabetes, heart disease, and other serious health conditions.

The bacteria within an individual's gut can influence their susceptibility to these disorders. Therefore, altering the microbe population in the gut could prevent or reverse disease.

A June 24th study in the Journal of Clinical Investigation demonstrates that modified bacteria can prevent weight gain in mice. Sean Davies and colleagues at Vanderbilt University made bacteria that produce a compound called NAPE, which signals to the brain to stop eating.

Mice that consumed NAPE-producing bacteria in their water ate less when given high fat food, which limited and associated symptoms.

More information: Paper: Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity, J Clin Invest. DOI: 10.1172/JCI72517

Related Stories

Chronic intake of Western diet kills mice

date Jun 19, 2014

(Medical Xpress)—When Cornell researchers fed high-fat Western diets to mice engineered without key immune system receptors to recognize pathogens, the mice died from lethal lung damage.

Recommended for you

Shedding light on rods

date 1 hour ago

By using "unusual" optic fibres in a novel fashion, an international team of researchers led by the International School for Advanced Studies (SISSA) in Trieste, scrutinized the response to light of rods, ...

Study finds inhibitor for COPD lung destruction

date 17 hours ago

In a new study, a research team based at Brown and Yale implicates a specific mitochondrial protein and pathway in the development of chronic obstructive pulmonary disease (COPD) from exposure to cigarette ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.