Case study shows importance of single-pill HIV-1 treatment

Case study shows importance of single-pill HIV-1 treatment

(HealthDay)—A single-pill combination HIV-1 treatment may be appropriate in certain cases, according to a case vignette published in the July 17 issue of the New England Journal of Medicine.

Monica Gandhi, M.D., M.P.H., from the University of California in San Francisco, and Rajesh T. Gandhi, M.D., from Massachusetts General Hospital in Boston, discuss the case of a 52-year-old homeless man who was diagnosed with HIV-1 infection in 2005. The patient was recently prescribed a multi-pill antiretroviral regimen, which he had not followed. The patient, who did not take other medications and had normal renal function, would take his medication if it was limited to a single pill once a day.

The authors discuss the currently available single-pill combinations marketed for HIV-1 treatment, each of which contains the same combination of one nucleotide reverse-transcriptase inhibitor and one nucleoside reverse-transcriptase inhibitor. After checking the HIV-1 genotype of the patient for drug resistance, a single-pill combination could be beneficial in this case. Tenofovir disoproxil fumarate and emtricitabine would be a reasonable option as a backbone in the single-pill combination, and any of the anchor drugs would be suitable for this patient, based on his having normal .

"The selection of a regimen should be based on potential side effects, food requirements, dosing schedule, and, possibly, anticipated adherence; cost may also be a consideration," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

US approves new HIV drug

May 21, 2011

The US Food and Drug Administration on Friday approved a new drug, Edurant, to fight HIV in combination with other antiretrovirals already on the market.

Recommended for you

New study reveals why some people may be immune to HIV-1

Nov 20, 2014

Doctors have long been mystified as to why HIV-1 rapidly sickens some individuals, while in others the virus has difficulties gaining a foothold. Now, a study of genetic variation in HIV-1 and in the cells ...

Virus discovery could impact HIV drug research

Nov 20, 2014

A research team led by Portland State University (PSU) biology professor Ken Stedman has unlocked the structure of an unusual virus that lives in volcanic hot springs. The discovery could pave the way for better drugs to ...

UN warns over threat of AIDS rebound

Nov 19, 2014

South African actress Charlize Theron threw her weight Tuesday behind an urgent new UN campaign to end AIDS as a global health threat by 2030.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.