Dyslexic readers have disrupted network connections in the brain

Dyslexia, the most commonly diagnosed learning disability in the United States, is a neurological reading disability that occurs when the regions of the brain that process written language don't function normally.

The use of non-invasive functional neuroimaging tools has helped characterize how brain activity is disrupted in . However, most prior work has focused on only a small number of brain regions, leaving a gap in our understanding of how multiple brain regions communicate with one another through networks, called , in persons with dyslexia.

This led neuroscience PhD student Emily Finn and her colleagues at the Yale University School of Medicine to conduct a whole-brain functional connectivity analysis of dyslexia using functional magnetic resonance imaging (fMRI). They report their findings in the current issue of Biological Psychiatry.

"In this study, we compared fMRI scans from a large number of both children and young adults with dyslexia to scans of typical readers in the same age groups. Rather than activity in isolated brain regions, we looked at functional connectivity, or coordinated fluctuations between pairs of brain regions over time," explained Finn.

In total, they recruited and scanned 75 children and 104 adults. Finn and her colleagues then compared the whole-brain connectivity profiles of the dyslexic readers to the non-impaired readers, which revealed widespread differences.

Dyslexic readers showed decreased connectivity within the visual pathway as well as between visual and prefrontal regions, increased right-hemisphere connectivity, reduced connectivity in the visual word-form area, and persistent connectivity to anterior language regions around the inferior frontal gyrus. This altered connectivity profile is consistent with dyslexia-related reading difficulties.

Dr. John Krystal, Editor of Biological Psychiatry, said, "This study elegantly illustrates the value of functional imaging to map circuits underlying problems with cognition and perception, in this case, dyslexia."

"As far as we know, this is one of the first studies of dyslexia to examine differences in functional connectivity across the whole brain, shedding light on the brain networks that crucially support the complex task of reading," added Finn. "Compared to typical readers, dyslexic readers had weaker connections between areas that process visual information and areas that control attention, suggesting that individuals with dyslexia are less able to focus on printed words."

Additionally, young-adult maintained high connectivity to involved in phonology, suggesting that they continue to rely on effortful "sounding out" strategies into adulthood rather than transitioning to more automatic, visual-based strategies for word recognition.

A better understanding of brain organization in dyslexia could potentially lead to better interventions to help struggling readers.

More information: The article is "Disruption of Functional Networks in Dyslexia: A Whole-Brain, Data-Driven Analysis of Connectivity" by Emily S. Finn, Xilin Shen, John M. Holahan, Dustin Scheinost, Cheryl Lacadie, Xenophon Papademetris, Sally E. Shaywitz, Bennett A. Shaywitz, and R. Todd Constable (DOI: 10.1016/j.biopsych.2013.08.031). The article appears in Biological Psychiatry, Volume 76, Issue 5 (September 1, 2014)

add to favorites email to friend print save as pdf

Related Stories

Hear Jane read: Researcher gives new meaning to semantics

Jul 15, 2014

For years a key way of diagnosing dyslexia has been how well a person reads aloud. Similarly, the reading skills of adult readers also have been assessed by having them read words aloud. "The idea is that the more you read ...

Recommended for you

Mother-daughter research team studies severe-weather phobia

Sep 19, 2014

No one likes severe weather, but for some just the thought of a thunderstorm, tornado, hurricane or blizzard can severely affect their lives. When blood pressures spike, individuals obsessively monitor weather forecasts and ...

Study: Pupil size shows reliability of decisions

Sep 18, 2014

Te precision with which people make decisions can be predicted by measuring pupil size before they are presented with any information about the decision, according to a new study published in PLOS Computational Bi ...

User comments