Intrinsic imaging phenotypes ID breast cancer recurrence

August 5, 2014
Intrinsic imaging phenotypes ID breast cancer recurrence

(HealthDay)—Computer-extracted morphologic, kinetic, and tumor heterogeneity dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging features can help predict the likelihood of breast cancer recurrence, according to a study published in the August issue of Radiology.

Ahmed Bilal Ashraf, Ph.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues retrospectively analyzed DCE MR images of the breast in 56 women (mean age, 55.6 years) diagnosed with estrogen receptor-positive between 2005 and 2010. A gene expression assay was used to score the likelihood of recurrence of primary tumors. For each tumor, a multiparametric imaging phenotype vector was extracted using quantitative morphologic, kinetic, and spatial heterogeneity features.

The researchers observed a moderate correlation (P < 0.001) between DCE MR imaging features and the score. Recurrence risk was predicted by DCE MR imaging features as determined by the surrogate assay, with an area under the receiver operating characteristic curve of 0.77 (P < 0.01). Four dominant imaging phenotypes were detected; two included only low- and medium-risk tumors. The area under the curve increased to 0.82 (P < 0.01) when the phenotype category was used as an additional variable.

"These imaging biomarkers could ultimately help guide treatment decisions," the authors write.

One author disclosed financial ties to Hologic.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Molecular imaging finds novel way to knock down breast cancer

June 9, 2014

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells—specifically those testing positive for human epidermal growth factor receptor 2 (HER2). A recent ...

Diet may affect risk recurrence of some breast cancers

June 20, 2014

(HealthDay)—Personalized dietary recommendations based on molecular characteristics of primary tumor tissue may be an effective strategy for breast cancer survivors, according to research published in the July issue of ...

Recommended for you

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

New treatment options for a fatal leukemia

July 27, 2015

In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the Universities of Zurich and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.