Intrinsic imaging phenotypes ID breast cancer recurrence

Intrinsic imaging phenotypes ID breast cancer recurrence

(HealthDay)—Computer-extracted morphologic, kinetic, and tumor heterogeneity dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging features can help predict the likelihood of breast cancer recurrence, according to a study published in the August issue of Radiology.

Ahmed Bilal Ashraf, Ph.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues retrospectively analyzed DCE MR images of the breast in 56 women (mean age, 55.6 years) diagnosed with estrogen receptor-positive between 2005 and 2010. A gene expression assay was used to score the likelihood of recurrence of primary tumors. For each tumor, a multiparametric imaging phenotype vector was extracted using quantitative morphologic, kinetic, and spatial heterogeneity features.

The researchers observed a moderate correlation (P < 0.001) between DCE MR imaging features and the score. Recurrence risk was predicted by DCE MR imaging features as determined by the surrogate assay, with an area under the receiver operating characteristic curve of 0.77 (P < 0.01). Four dominant imaging phenotypes were detected; two included only low- and medium-risk tumors. The area under the curve increased to 0.82 (P < 0.01) when the phenotype category was used as an additional variable.

"These imaging biomarkers could ultimately help guide treatment decisions," the authors write.

One author disclosed financial ties to Hologic.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Diet may affect risk recurrence of some breast cancers

Jun 20, 2014

(HealthDay)—Personalized dietary recommendations based on molecular characteristics of primary tumor tissue may be an effective strategy for breast cancer survivors, according to research published in the ...

Molecular imaging finds novel way to knock down breast cancer

Jun 09, 2014

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells—specifically those testing positive for human epidermal growth factor receptor 2 (HER2). A recent ...

Recommended for you

ACG: Recent increase in incidence of young-onset CRC

9 hours ago

(HealthDay)—The incidence of young-onset colorectal cancer (CRC) is increasing, and the disease is more aggressive pathologically. These findings are being presented at the annual meeting of the American ...

User comments