Improving lymphatic function protects mice from experimental colitis

Chronic inflammatory bowel disease can be painful and debilitating. Both genetics and environment are thought to promote disease, but it is not fully understood how chronic IBD develops. Emerging evidence indicates that IBD is associated with an increase in lymphatic vasculature, which transports lymph throughput the body. It is not clear if these lymphatic vessels promote or improve IBD.

A new study in the Journal of Clinical Investigation indicates that improving lymphatic function relieves experimental IBD in mice. Silvio Danese and colleagues at Humanitas Clinical and Research Center gave mice a compound called VEGF-C that improves lymphatic function prior to the onset of experimental IBD. VEGF-C treatment prevented development of both chronic and acute IBD.

This study indicates that augmenting lymphatic function helps prevent and suggests that VEGF-C should be further tested for use in IBD.

More information: VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease, J Clin Invest. DOI: 10.1172/JCI72189

add to favorites email to friend print save as pdf

Related Stories

Two genes linked to inflammatory bowel disease

Apr 22, 2014

Inflammatory Bowel Disease (IBD), a group of chronic inflammatory disorders of the intestine that result in painful and debilitating complications, affects over 1.4 million people in the U.S., and while there are treatments ...

Melanoma risk up in IBD independent of biologic therapy

Jan 31, 2014

(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Ga ...

Recommended for you

WHO: Ebola vaccine trials in W. Africa in January

11 hours ago

Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe, a top World Health Organization official ...

Ebola cases rise sharply in western Sierra Leone

11 hours ago

After emerging months ago in eastern Sierra Leone, Ebola is now hitting the western edges of the country where the capital is located with dozens of people falling sick each day, the government said Tuesday. So many people ...

User comments