Improving lymphatic function protects mice from experimental colitis

August 8, 2014

Chronic inflammatory bowel disease can be painful and debilitating. Both genetics and environment are thought to promote disease, but it is not fully understood how chronic IBD develops. Emerging evidence indicates that IBD is associated with an increase in lymphatic vasculature, which transports lymph throughput the body. It is not clear if these lymphatic vessels promote or improve IBD.

A new study in the Journal of Clinical Investigation indicates that improving lymphatic function relieves experimental IBD in mice. Silvio Danese and colleagues at Humanitas Clinical and Research Center gave mice a compound called VEGF-C that improves lymphatic function prior to the onset of experimental IBD. VEGF-C treatment prevented development of both chronic and acute IBD.

This study indicates that augmenting lymphatic function helps prevent and suggests that VEGF-C should be further tested for use in IBD.

Explore further: Melanoma risk up in IBD independent of biologic therapy

More information: VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease, J Clin Invest. DOI: 10.1172/JCI72189

Related Stories

Melanoma risk up in IBD independent of biologic therapy

January 31, 2014

(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Gastroenterology ...

Two genes linked to inflammatory bowel disease

April 22, 2014

Inflammatory Bowel Disease (IBD), a group of chronic inflammatory disorders of the intestine that result in painful and debilitating complications, affects over 1.4 million people in the U.S., and while there are treatments ...

Low vitamin D levels tied to increased cancer risk in IBD

May 6, 2014

(HealthDay)—Low plasma levels of 25-hydroxyvitamin D (25[OH]D) are associated with an increased risk of cancer in patients with inflammatory bowel diseases (IBD), according to a study published in the May issue of Clinical ...

Recommended for you

Monkeys in Asia harbor virus from humans, other species

November 19, 2015

When it comes to spreading viruses, bats are thought to be among the worst. Now a new study of nearly 900 nonhuman primates in Bangladesh and Cambodia shows that macaques harbor more diverse astroviruses, which can cause ...

One-step test for hepatitis C virus infection developed

November 14, 2015

UC Irvine Health researchers have developed a cost-effective one-step test that screens, detects and confirms hepatitis C virus (HCV) infections. Dr. Ke-Qin Hu, director of hepatology services, will present findings at the ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.