Vitamin D deficiency during pregnancy may increase risk of MS in children

March 7, 2016

Children of mothers with vitamin D deficiency during early pregnancy appeared to be at greater risk for multiple sclerosis (MS) in adulthood, according to an article published online by JAMA Neurology.

While elevated levels of vitamin D have been associated with a decreased risk of MS in adulthood, some previous research also has suggested that vitamin D exposure in utero may be a risk factor for MS in later life.

Kassandra L. Munger, Sc.D., of the Harvard T.H. Chan School of Public Health, Boston, and coauthors examined whether serum 25-hydroxyvitamin D (25[OH]D) levels in were associated with the risk of MS in children.

The authors identified 193 individuals (163 of them female) with a diagnosis of MS whose mothers were part of the Finnish Maternity Cohort and matched 176 case patients with 326 control participants for comparison.

The majority of maternal blood samples (70 percent) to measure 25(OH)D levels had been collected during the first trimester and the average maternal vitamin D levels were in the insufficient vitamin D range.

The risk of MS as an adult was 90 percent higher in children of mothers who were vitamin-D deficient (25(OH)D levels less than 12.02 ng/mL) compared with the children of mothers who were not vitamin D deficient, according to the results.

The authors note that two prior studies examining the association between 25(OH)D levels in pregnancy/early life did not find an association with future MS risk in children. In the current study, the authors note a few limitations, including that maternal 25(OH)D levels during pregnancy are not a direct measure of the 25(OH)D levels to which the developing fetus is exposed.

The study concludes that "while our results suggest that D deficiency during pregnancy increases MS risk in the offspring, our study does not provide any information as to whether there is a dose-response effect with increasing levels of 25(OH)D sufficiency. Similar studies in populations with a wider distribution of 25(OH)D are needed."

"The study was made possible by biobanking efforts in Finland as part of the Finnish Maternity Cohort (FMC). ... When the FMC was established, it was not intended to create a resource for MS research, but its existence has created a powerful tool for understanding complex biology and disease," writes Benjamin M. Greenberg, M.D., M.H.S., of the University of Texas Southwestern, Dallas, in a related editorial.

Explore further: High-dose vitamin D may not be better than low-dose vitamin D in treating MS

More information: JAMA Neurol. Published online March 7, 2016. DOI: 10.1001/jamaneurol.2015.4800
JAMA Neurol. Published online March 7, 2016. DOI: 10.1001/jamaneurol.2016.0018

Related Stories

Taking vitamin D may benefit people with multiple sclerosis

December 30, 2015

Taking a high dose of vitamin D3 is safe for people with multiple sclerosis and may help regulate the body's hyperactive immune response, according to a pilot study published by Johns Hopkins physicians in the Dec. 30 online ...

Maternal B12 levels impact children's cardiometabolic health

February 12, 2016

(HealthDay)—Mothers' vitamin B12 levels in early pregnancy may impact children's cardiometabolic risk factors at age 5 years, according to a study published in the February issue of BJOG: An International Journal of Obstetrics ...

Recommended for you

Neuroscience study supports 200-year old art theory

September 19, 2016

A pilot study from a group of Dutch scientists implies that being told that an image is an artwork automatically changes our response, both on a neural and behavioural level. This may mean that our brains automatically up- ...

Human neuron transplants treat spinal cord injury in mice

September 23, 2016

Chronic pain and loss of bladder control are among the most devastating consequences of spinal cord injury, rated by many patients as a higher priority for treatment than paralysis or numbness. Now a UC San Francisco team ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.