American Association for Cancer Research
Visceral fat causally linked to intestinal cancer
Visceral fat, or fat stored deep in the abdominal cavity, is directly linked to an increased risk for colon cancer, according to data from a mouse study published in Cancer Prevention Research, a journal of the American Associ ...
Cancer
Mar 06, 2013 |
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Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer
An increasing body mass index was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according ...
Cancer
Feb 26, 2013 |
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Biomarker may identify neuroblastomas with sensitivity to BET bromodomain inhibitors
Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors ...
Cancer
Feb 21, 2013 |
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New drug combination could prevent head and neck cancer in high-risk patients
(Medical Xpress)—A new drug combination shows promise in reducing the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included ...
Cancer
Feb 19, 2013 |
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MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
Researchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer, according to data published in Cancer Research, a publication of the Americ ...
Cancer
Feb 05, 2013 |
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Common genetic alteration found in head and neck cancers may not be key to effective treatment
Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that d ...
Cancer
Jan 29, 2013 |
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Treatment targeting PI3K may delay resistance to anti-HER2 therapy in breast cancer patients
Patients with HER2-positive breast cancer being treated with anti-HER2 therapy may be able to prevent or delay resistance to the therapy with the addition of a phosphatidylinositol-3 kinase inhibitor to their treatment regimens.
Cancer
Jan 23, 2013 |
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New test predicted presence of harmful BRCA mutations
A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a jour ...
Cancer
Jan 22, 2013 |
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New model may help predict response to chemotherapy for colorectal cancer
Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy using a new mathematical model that measures the amount of stress required for a cancer cell to die without harming ...
Cancer
Jan 17, 2013 |
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Preventing prostate cancer through androgen deprivation may have harmful effects
Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation ...
Cancer
Dec 20, 2012 |
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Hard-to-treat Myc-driven cancers may be susceptible to drug already used in clinic
Drugs that are used in the clinic to treat some forms of breast and kidney cancer and that work by inhibiting the signaling molecule mTORC1 might have utility in treating some of the more than 15 percent of human cancers ...
Cancer
Dec 14, 2012 |
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New screening approach identified potential drug combos for difficult-to-treat melanomas
A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating ...
Cancer
Dec 13, 2012 |
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Obesity and overeating during menopause together promote breast tumor growth and progression
Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, ...
Cancer
Dec 07, 2012 |
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Hypofractionated radiotherapy was safe, effective for early breast cancer treatment at 10-year follow-up
Appropriately dosed hypofractionated radiotherapy was gentle on healthy tissues and effective in controlling local-regional early breast cancer, according to 10-year follow-up results from the U.K. Standardization of Breast ...
Cancer
Dec 07, 2012 |
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Diverse genetic alterations found in triple-negative breast cancers after neoadjuvant chemotherapy
Many different genetic alterations were detected in tumor cells left behind after patients with triple-negative breast cancer were treated with chemotherapy prior to surgery (neoadjuvant chemotherapy), according to data presented ...
Cancer
Dec 07, 2012 |
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