Children's Hospital Boston

Arthritis & Rheumatism

Why inflammatory arthritis always recurs in certain joints

When joints flare up in people with rheumatoid arthritis and related diseases, the joints involved are often the same as those affected before. For example, if arthritis started in the right knee, it is much more likely to ...

Biomedical technology

Mimicking nature to provide long-lasting local anesthesia

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an ...

Medications

ADHD drug class leads to fewer side effects in preschool children

About 2.4 percent of preschool-age children have an attention-deficit/hyperactivity disorder (ADHD) diagnosis. For these children, behavioral interventions intended to redirect a child or otherwise replace negative behaviors ...

Diseases, Conditions, Syndromes

Why do some people get severe COVID-19? The nose may know

The body's first encounter with SARS-CoV-2, the virus behind COVID-19, happens in the nose and throat, or nasopharynx. A new study in the journal Cell suggests that the first responses in this battleground help determine ...

Diabetes

A coming wave of diabetes? The link with COVID-19

Researchers are observing a new long-term health concern in patients hospitalized with COVID-19—an increase in new-onset hyperglycemia lasting months after infection. An Italian study found that about half of the patients ...

Genetics

A 'pump' gene's surprising role in early brain formation

In polymicrogyria, the cortex of the brain has many irregular, small folds (gyria) and disorganization of its layers. Many affected children have severe developmental delay, intellectual disabilities, and epilepsy, and many ...

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