Cold Spring Harbor Laboratory

Neuroscientists show 'jumping genes' may contribute to aging-related brain defects

As the body ages, the physical effects are notable; wrinkles in the skin appear, physical exertion becomes harder. But there are also less visible processes going on. Inside aging brains there is another phenomenon at work, ...

Neuroscience created Apr 08, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Neuroscientists pinpoint location of fear memory in amygdala

A rustle of undergrowth in the outback: it's a sound that might make an animal or person stop sharply and be still, in the anticipation of a predator. That "freezing" is part of the fear response, a reaction to a stimulus ...

Neuroscience created Jan 28, 2013 | popularity 5 / 5 (2) | comments 2 | with audio podcast

Study solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells

A team at CSHL for the 1st time reveals the birth timing and embryonic origin of a critical class of inhibitory brain cells called chandelier cells, tracing the specific paths they take during early development into the cerebral ...

Neuroscience created Nov 22, 2012 | popularity 5 / 5 (3) | comments 2 | with audio podcast

Scientists reverse Alzheimer's-like memory loss in animal models by blocking EGFR signaling

A team of neuroscientists and chemists from the U.S. and China today publish research suggesting that a class of currently used anti-cancer drugs as well as several previously untested synthetic compounds show effectiveness ...

Alzheimer's disease & dementia created Sep 24, 2012 | popularity 4.8 / 5 (4) | comments 0 | with audio podcast

Differences between human twins at birth highlight importance of intrauterine environment

Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published online in Genome Research, researchers have f ...

Genetics created Jul 15, 2012 | popularity 4.5 / 5 (4) | comments 9 | with audio podcast

Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers

Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer ...

Cancer created May 07, 2012 | popularity not rated yet | comments 0 | with audio podcast

A striking link is found between the Fragile-X gene and mutations that cause autism

A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein ...

Genetics created Apr 25, 2012 | popularity not rated yet | comments 0 | with audio podcast

Possible link between bacterium, colon cancer found

For the first time, a specific microorganism has been found to be associated with human colorectal cancer. In two studies published online today in Genome Research, independent research teams have identified Fusobacterium in col ...

Cancer created Oct 17, 2011 | popularity 5 / 5 (5) | comments 0 | with audio podcast

New evidence for genetic basis of autism found

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. ...

Genetics created Oct 03, 2011 | popularity 4.3 / 5 (9) | comments 6 | with audio podcast

Team perfects non-lethal way of switching off essential genes in mice

One way of discovering a gene's function is to switch it off and observe how the loss of its activity affects an organism. If a gene is essential for survival, however, then switching it off permanently will ...

Genetics created Apr 14, 2011 | popularity 5 / 5 (3) | comments 5 | with audio podcast

Rats take high-speed multisensory snapshots

When animals are on the hunt for food they likely use many senses, and scientists have wondered how the different senses work together. New research from the laboratory of CSHL neuroscientist and Assistant Professor Adam ...

Neuroscience created May 07, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Scientists discover how brain's auditory center transmits information for decisions, actions

When a pedestrian hears the screech of a car's brakes, she has to decide whether, and if so, how, to move in response. Is the action taking place blocks away, or 20 feet to the left?

Neuroscience created May 01, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

A novel surface marker helps scientists 'fish out' mammary gland stem cells

Stem cells are different from all other cells in our body because they retain the remarkable genetic plasticity to self-renew indefinitely as well as develop into cell types with more specialized functions. However, this ...

Cancer created Apr 11, 2013 | popularity 4 / 5 (1) | comments 0 | with audio podcast

Cancer-promoting protein found to also suppress cell growth

Some cellular proteins have multiple, and occasionally opposing, functions. Professor Adrian Krainer [link: Faculty profile] and colleagues at Cold Spring Harbor Laboratory demonstrate in a paper published online today in ...

Medical research created Mar 07, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Researchers identify new strategy for interfering with potent cancer-causing gene

Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible ...

Cancer created Feb 11, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast